Ubiquitous Plasticity and Memory Storage

Sang Jeong Kim, David J. Linden

Research output: Contribution to journalReview article

Abstract

To date, most hypotheses of memory storage in the mammalian brain have focused upon long-term synaptic potentiation and depression (LTP and LTD) of fast glutamatergic excitatory postsynaptic currents (EPSCs). In recent years, it has become clear that many additional electrophysiological components of neurons, from electrical synapses to glutamate transporters to voltage-sensitive ion channels, can also undergo use-dependent long-term plasticity. Models of memory storage that incorporate this full range of demonstrated electrophysiological plasticity are better able to account for both the storage of memory in neuronal networks and the complexities of memory storage, indexing, and recall as measured behaviorally.

Original languageEnglish (US)
Pages (from-to)582-592
Number of pages11
JournalNeuron
Volume56
Issue number4
DOIs
StatePublished - Nov 21 2007

ASJC Scopus subject areas

  • Neuroscience(all)

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