[Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat

Hunter C. Champion, Trinity J. Bivalacqua, Run Wang, Wayne J.G. Hellstrom, Philip J. Kadowitz

Research output: Contribution to journalArticle

Abstract

The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein-coupled receptor ORL1. The present study was undertaken to investigate responses to intracavernosal injections of the nociceptin analog [Tyr1]-nociceptin and to investigate the effects of naloxone on erectile responses in anesthetized cats to [Tyr1]-nociceptin and to nociceptin. Intracavernosal injections of [Tyr1]-nociceptin and of nociceptin in doses of 0.3-30 nmol elicited dose- related increases in cavernosal pressure, which, at the highest dose studied, were comparable to increases induced by the triple-drug standard (papaverine, phentolamine, and prostaglandin E,), a preparation used in the treatment of erectile dysfunction. Responses to [Tyr1]-nociceptin were rapid in onset and had a time course similar to responses to nociceptin. Metenkephalin increased cavernosal pressure, whereas injections of nociceptin-(2-17), dynorphin A, and β-endorphin did not alter cavernosal pressure. Erectile responses to nociceptin and to [Tyr1]-nociceptin were not altered after administration of the opioid receptor antagonist naloxone at a time when erectile responses to metenkephalin were attenuated: These data show that [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalJournal of andrology
Volume19
Issue number6
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Hypotensive activity
  • Intracavernosal injection
  • Orphanin FQ
  • Penile erection

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

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  • Cite this

    Champion, H. C., Bivalacqua, T. J., Wang, R., Hellstrom, W. J. G., & Kadowitz, P. J. (1998). [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat. Journal of andrology, 19(6), 747-753.