Tyrosine phosphorylation of NMDA receptor in rat striatum: Effects of 6-OH-dopamine lesions

Mathia Menegoz, Lit Fui Lau, Denis Herve, Richard L. Huganir, Jean Antoine Girault

Research output: Contribution to journalArticlepeer-review

Abstract

N-METHYL-D-aspartate (NMDA) glutamate receptor properties are subject to a fine tuning by several regulatory mechanisms including phosphorylation of the receptor subunits. Here we show that two of these subunits, NR2B and NR2A, are phosphorylated on tyrosine residues in vivo, in rat striatum, where NR2B is by far the most prominent tyrosine phosphorylated protein. Two weeks after unilateral lesioning of nigro-striatal dopaminergic neurones with 6-hydroxydopa-mine, tyrosine phosphorylation of NR2B was increased by ~20% in the ipsilateral striatum. The total amount of NR2B protein was unaltered. Thus, increased tyrosine phosphorylation of NR2B may account for some of the consequences of dopamine deprivation on corticostriatal transmission and may play a role in some forms of synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)125-128
Number of pages4
JournalNeuroreport
Volume7
Issue number1
DOIs
StatePublished - Dec 29 1995

Keywords

  • 6-OH-dopamine
  • Corticostriatal pathway
  • Dopamine
  • NMDA receptor
  • NR2A
  • NR2B
  • Neuronal lesions
  • Nigrostriatal pathway
  • Striatum
  • Tyrosine phosphorylation

ASJC Scopus subject areas

  • Neuroscience(all)

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