Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation

Zhou Zhu, Sun Young Oh, You Sook Cho, Li Zhang, Yoon Keun Kim, Tao Zheng

Research output: Contribution to journalReview articlepeer-review

Abstract

Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.

Original languageEnglish (US)
Pages (from-to)3-13
Number of pages11
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 2010

Keywords

  • Allergic inflammatory response
  • Allergy
  • Asthma
  • Mast cells
  • Phosphatase
  • Th2 cytokines

ASJC Scopus subject areas

  • Immunology

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