Tyrosine Kinase Inhibitor Use and Wound Healing in Tracheoesophageal Punctures

Christopher J. Britt, Jonathon Russell

Research output: Contribution to journalArticle

Abstract

Tyrosine kinase inhibitors (TKIs) aid in prolonging life in patients with advanced locoregional thyroid malignancy. Such patients may undergo total laryngectomy for local disease control and tracheoesophageal puncture (TEP) for speech rehabilitation. Enlargement of TEP fistulas is usually attributed to wound healing issues and leads to major complications. Four laryngectomies with TEP were performed between 2015 and 2016 and subsequently placed on a TKI. Three patients developed a complication after TKI treatment, and 2 patients had a tracheoesophageal fistula. Patients should be counseled about possible wound healing risks associated with TKIs.

Original languageEnglish (US)
JournalEar, Nose and Throat Journal
DOIs
StatePublished - Jan 1 2019

Fingerprint

Punctures
Protein-Tyrosine Kinases
Wound Healing
Tracheoesophageal Fistula
Laryngectomy
TYK2 Kinase
Thyroid Gland
Rehabilitation
Neoplasms
Therapeutics

Keywords

  • biologics
  • laryngectomy
  • prosthesis
  • TEP
  • thyroid cancer
  • thyroid carcinoma
  • thyroidectomy
  • TKI
  • tracheoesophageal fistula
  • tyrosine kinase inhibitor
  • wound healing

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Tyrosine Kinase Inhibitor Use and Wound Healing in Tracheoesophageal Punctures. / Britt, Christopher J.; Russell, Jonathon.

In: Ear, Nose and Throat Journal, 01.01.2019.

Research output: Contribution to journalArticle

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