Abstract
Long-term therapy with tyrosine kinase inhibitors (TKI) has resulted in improved outcomes for patients suffering from Bcr-Abl fusion protein-harboring leukemias. As a result, a growing population of patients on TKI therapy present to their primary care providers. In this case, we report on the case of a 62-year-old male who presented with a symptomatic pericardial effusion. After pericardiocentesis, malignancy and infectious etiologies were excluded. The pericardial effusion was attributed to his TKI, with a transition of this medication to a different TKI. A repeat evaluation 1 month following the withdrawal of the offending agent showed no recurrence of his pericardial effusion on echocardiogram. In this report, we will highlight a rare but important side effect of TKI therapy before discussing its purported mechanisms and differing incidence rates. Early recognition of serosal inflammation related to long-term TKI therapy by primary care providers is important in preventing patient morbidity and mortality.
Original language | English (US) |
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Pages (from-to) | 88-93 |
Number of pages | 6 |
Journal | Case Reports in Oncology |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - May 22 2015 |
Keywords
- Leukemia
- Pericardial effusion
- Tyrosine kinase inhibitor
ASJC Scopus subject areas
- Oncology