Type-restricted neutralization of molecular clones of human immunodeficiency virus

David J. Looney, Amanda G. Fisher, Scott D. Putney, James R. Rusche, Robert R. Redfield, Donald S. Burke, Robert C. Gallo, F. Wong-Staal

Research output: Contribution to journalArticle


In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1-infected patients and from goats immunized with polyacrylamide gel-purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such "clonal restriction" of neutralizing activity.

Original languageEnglish (US)
Pages (from-to)357-359
Number of pages3
Issue number4863
Publication statusPublished - 1988
Externally publishedYes


ASJC Scopus subject areas

  • General

Cite this

Looney, D. J., Fisher, A. G., Putney, S. D., Rusche, J. R., Redfield, R. R., Burke, D. S., ... Wong-Staal, F. (1988). Type-restricted neutralization of molecular clones of human immunodeficiency virus. Science, 241(4863), 357-359.