Type II collagen arthritis: Identification of arthritogenic epitopes using fractionated anticollagen IgG

Mary E. Englert, Kim M. Ferguson, Carmen R. Suarez, Theresa M. Sapp, Arnold L. Oronsky, S. S. Kerwar

Research output: Contribution to journalArticlepeer-review

Abstract

Affinity-purified anticollagen IgG was fractionated on purified cyanogen bromide-derived collagen peptide Sepharose. The antibody fraction bound to the peptides was eluted and tested for its ability to induce passive arthritis in recipients. Anticollagen IgG bound to peptide 5 (α1(II)-CB8-10 and α1(II)CB11-8) and to peptide 6 (α1(II)CB11) were active in inducing passive arthritis. Other peptide bound fractions were inactive. These observations suggest that the arthritogenic domain in Type II collagen is restricted to α1(II)CB11.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalCellular Immunology
Volume105
Issue number2
DOIs
StatePublished - Apr 1 1987

ASJC Scopus subject areas

  • Immunology

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