Type 2 hyperprolinemia: Absence of Δ1-pyrroline-5- carboxylic acid dehydrogenase activity

David L. Valle; James M. Phang; Stephen I. Goodman

doi:10.1126/science.185.4156.1053

Type 2 hyperprolinemia: Absence of Δ¹-pyrroline-5- carboxylic acid dehydrogenase activity

David L. Valle, James M. Phang, Stephen I. Goodman

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Abstract

Δ¹-Pyrroline-5-carboxylic acid dehydrogenase activity was measured radioisotopically in normal and type 2 hyperprolinemia fibroblasts. The type 2 cells had no detectable activity over a range of reaction conditions whereas normal cells had easily measurable activity. This enzymatic defect accounts for the biochemnical abnormalities in type 2 hyperprolinemia.

Original language	English (US)
Pages (from-to)	1053-1054
Number of pages	2
Journal	Science
Volume	185
Issue number	4156
DOIs	https://doi.org/10.1126/science.185.4156.1053
State	Published - 1974
Externally published	Yes

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title = "Type 2 hyperprolinemia: Absence of Δ1-pyrroline-5- carboxylic acid dehydrogenase activity",

abstract = "Δ1-Pyrroline-5-carboxylic acid dehydrogenase activity was measured radioisotopically in normal and type 2 hyperprolinemia fibroblasts. The type 2 cells had no detectable activity over a range of reaction conditions whereas normal cells had easily measurable activity. This enzymatic defect accounts for the biochemnical abnormalities in type 2 hyperprolinemia.",

author = "Valle, {David L.} and Phang, {James M.} and Goodman, {Stephen I.}",

year = "1974",

doi = "10.1126/science.185.4156.1053",

language = "English (US)",

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TY - JOUR

T1 - Type 2 hyperprolinemia

T2 - Absence of Δ1-pyrroline-5- carboxylic acid dehydrogenase activity

AU - Valle, David L.

AU - Phang, James M.

AU - Goodman, Stephen I.

PY - 1974

Y1 - 1974

N2 - Δ1-Pyrroline-5-carboxylic acid dehydrogenase activity was measured radioisotopically in normal and type 2 hyperprolinemia fibroblasts. The type 2 cells had no detectable activity over a range of reaction conditions whereas normal cells had easily measurable activity. This enzymatic defect accounts for the biochemnical abnormalities in type 2 hyperprolinemia.

AB - Δ1-Pyrroline-5-carboxylic acid dehydrogenase activity was measured radioisotopically in normal and type 2 hyperprolinemia fibroblasts. The type 2 cells had no detectable activity over a range of reaction conditions whereas normal cells had easily measurable activity. This enzymatic defect accounts for the biochemnical abnormalities in type 2 hyperprolinemia.

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Type 2 hyperprolinemia: Absence of Δ¹-pyrroline-5- carboxylic acid dehydrogenase activity

Abstract

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