Abstract
Aims There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics. Methods Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN. Results A total of 451 participants (mean age 61.1 ± 11.9 years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men. Conclusions An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 502-507 |
| Number of pages | 6 |
| Journal | Journal of Diabetes and its Complications |
| Volume | 29 |
| Issue number | 4 |
| DOIs | |
| State | Published - May 1 2015 |
| Externally published | Yes |
Fingerprint
Keywords
- Colorectal adenomas
- Colorectal cancer
- Colorectal neoplasia
- Hispanics
- Type 2 diabetes
- Type 2 DM
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
Cite this
Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics : A case-control study. / Díaz-Algorri, Yaritza; Lozada, María Eugenia; López, Sofía M.; Bertrán-Rodríguez, Carlos E.; González-Hernández, Cinthia M.; González, Dilka; Pérez-Cardona, Cynthia M.; Hernández, Jessica; Pedrosa, Carmen; Toro, Doris H.; González-Pons, María; Cruz-Correa, Marcia.
In: Journal of Diabetes and its Complications, Vol. 29, No. 4, 01.05.2015, p. 502-507.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics
T2 - A case-control study
AU - Díaz-Algorri, Yaritza
AU - Lozada, María Eugenia
AU - López, Sofía M.
AU - Bertrán-Rodríguez, Carlos E.
AU - González-Hernández, Cinthia M.
AU - González, Dilka
AU - Pérez-Cardona, Cynthia M.
AU - Hernández, Jessica
AU - Pedrosa, Carmen
AU - Toro, Doris H.
AU - González-Pons, María
AU - Cruz-Correa, Marcia
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Aims There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics. Methods Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN. Results A total of 451 participants (mean age 61.1 ± 11.9 years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men. Conclusions An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.
AB - Aims There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics. Methods Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN. Results A total of 451 participants (mean age 61.1 ± 11.9 years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men. Conclusions An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.
KW - Colorectal adenomas
KW - Colorectal cancer
KW - Colorectal neoplasia
KW - Hispanics
KW - Type 2 diabetes
KW - Type 2 DM
UR - http://www.scopus.com/inward/record.url?scp=84928609512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928609512&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2015.01.010
DO - 10.1016/j.jdiacomp.2015.01.010
M3 - Article
C2 - 25784088
AN - SCOPUS:84928609512
VL - 29
SP - 502
EP - 507
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 4
ER -