Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: A case-control study

Yaritza Díaz-Algorri, María Eugenia Lozada, Sofía M. López, Carlos E. Bertrán-Rodríguez, Cinthia M. González-Hernández, Dilka González, Cynthia M. Pérez-Cardona, Jessica Hernández, Carmen Pedrosa, Doris H. Toro, María González-Pons, Marcia Cruz-Correa

Research output: Contribution to journalArticlepeer-review


Aims There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics. Methods Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN. Results A total of 451 participants (mean age 61.1 ± 11.9 years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men. Conclusions An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.

Original languageEnglish (US)
Pages (from-to)502-507
Number of pages6
JournalJournal of Diabetes and its Complications
Issue number4
StatePublished - May 1 2015
Externally publishedYes


  • Colorectal adenomas
  • Colorectal cancer
  • Colorectal neoplasia
  • Hispanics
  • Type 2 diabetes
  • Type 2 DM

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine


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