Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: A case-control study

Yaritza Díaz-Algorri, María Eugenia Lozada, Sofía M. López, Carlos E. Bertrán-Rodríguez, Cinthia M. González-Hernández, Dilka González, Cynthia M. Pérez-Cardona, Jessica Hernández, Carmen Pedrosa, Doris H. Toro, María González-Pons, Marcia Cruz-Correa

Research output: Contribution to journalArticle

Abstract

Aims There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics. Methods Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN. Results A total of 451 participants (mean age 61.1 ± 11.9 years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men. Conclusions An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.

Original languageEnglish (US)
Pages (from-to)502-507
Number of pages6
JournalJournal of Diabetes and its Complications
Volume29
Issue number4
DOIs
StatePublished - May 1 2015
Externally publishedYes

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Hispanic Americans
Type 2 Diabetes Mellitus
Case-Control Studies
Neoplasms
Colorectal Neoplasms
Diabetes Mellitus
Colonoscopy
Adenoma
Confounding Factors (Epidemiology)
Early Detection of Cancer
Logistic Models
Odds Ratio

Keywords

  • Colorectal adenomas
  • Colorectal cancer
  • Colorectal neoplasia
  • Hispanics
  • Type 2 diabetes
  • Type 2 DM

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Díaz-Algorri, Y., Lozada, M. E., López, S. M., Bertrán-Rodríguez, C. E., González-Hernández, C. M., González, D., ... Cruz-Correa, M. (2015). Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: A case-control study. Journal of Diabetes and its Complications, 29(4), 502-507. https://doi.org/10.1016/j.jdiacomp.2015.01.010

Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics : A case-control study. / Díaz-Algorri, Yaritza; Lozada, María Eugenia; López, Sofía M.; Bertrán-Rodríguez, Carlos E.; González-Hernández, Cinthia M.; González, Dilka; Pérez-Cardona, Cynthia M.; Hernández, Jessica; Pedrosa, Carmen; Toro, Doris H.; González-Pons, María; Cruz-Correa, Marcia.

In: Journal of Diabetes and its Complications, Vol. 29, No. 4, 01.05.2015, p. 502-507.

Research output: Contribution to journalArticle

Díaz-Algorri, Y, Lozada, ME, López, SM, Bertrán-Rodríguez, CE, González-Hernández, CM, González, D, Pérez-Cardona, CM, Hernández, J, Pedrosa, C, Toro, DH, González-Pons, M & Cruz-Correa, M 2015, 'Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: A case-control study', Journal of Diabetes and its Complications, vol. 29, no. 4, pp. 502-507. https://doi.org/10.1016/j.jdiacomp.2015.01.010
Díaz-Algorri Y, Lozada ME, López SM, Bertrán-Rodríguez CE, González-Hernández CM, González D et al. Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: A case-control study. Journal of Diabetes and its Complications. 2015 May 1;29(4):502-507. https://doi.org/10.1016/j.jdiacomp.2015.01.010
Díaz-Algorri, Yaritza ; Lozada, María Eugenia ; López, Sofía M. ; Bertrán-Rodríguez, Carlos E. ; González-Hernández, Cinthia M. ; González, Dilka ; Pérez-Cardona, Cynthia M. ; Hernández, Jessica ; Pedrosa, Carmen ; Toro, Doris H. ; González-Pons, María ; Cruz-Correa, Marcia. / Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics : A case-control study. In: Journal of Diabetes and its Complications. 2015 ; Vol. 29, No. 4. pp. 502-507.
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T1 - Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics

T2 - A case-control study

AU - Díaz-Algorri, Yaritza

AU - Lozada, María Eugenia

AU - López, Sofía M.

AU - Bertrán-Rodríguez, Carlos E.

AU - González-Hernández, Cinthia M.

AU - González, Dilka

AU - Pérez-Cardona, Cynthia M.

AU - Hernández, Jessica

AU - Pedrosa, Carmen

AU - Toro, Doris H.

AU - González-Pons, María

AU - Cruz-Correa, Marcia

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Aims There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics. Methods Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN. Results A total of 451 participants (mean age 61.1 ± 11.9 years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men. Conclusions An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.

AB - Aims There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics. Methods Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN. Results A total of 451 participants (mean age 61.1 ± 11.9 years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men. Conclusions An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.

KW - Colorectal adenomas

KW - Colorectal cancer

KW - Colorectal neoplasia

KW - Hispanics

KW - Type 2 diabetes

KW - Type 2 DM

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