Two year prognosis of sarcoidosis

The ACCESS experience

Marc A. Judson, Robert P. Baughman, Bruce W. Thompson, Alvin S. Teirstein, Michael L. Terrin, Milton D. Rossman, Henry Yeager, Geoffrey McLennan, Eddy A. Bresnitz, Louis DePalo, Gary Hunninghake, Michael C. Iannuzzi, Carol J. Johns, David Moller, Lee S. Newman, David L. Rabin, Cecile Rose, Benjamin A. Rybicki, Steven E. Weinberger, Genell L. Knatterud & 1 others Reuben Cherniak

Research output: Contribution to journalArticle

Abstract

A cohort of 215 sarcoidosis patients from the ACCESS study underwent a clinical evaluation at study enrollment and two years later. Approximately 80% of subjects had an improved or stable FVC, FEV1, chest radiograph determined by Scadding stage, and dyspnea scale. African-Americans had less improvement in FVC than Caucasians (p = 0.04). Patients with erythema nodosum at presentation were more likely to have improvement in the chest radiograph at two-year follow-up (p = 0.007). Patients with a lower annual family income were more likely to worsen with respect to dyspnea (p = 0.01) and more likely to have new organ involvement at two-year follow-up (p = 0.045). The development of new organ involvement over the two year follow-up period was more common in African-Americans compared to Caucasians (p = 0.002) and more likely in those with extrapulmonary involvement at study entry (p = 0.003). There was an excellent concordance between changes in FVC and FEV1 over the two-year period. However, changes in FVC alone were inadequate to describe the change in pulmonary status of the patients, as changes in chest radiographic findings or the level of dyspnea did often but not always move in the same direction as FVC. In conclusion, data from this heterogeneous United States sarcoidosis population indicate that sarcoidosis tends to improve or remain stable over two years in the majority of patients. Several factors associated with improved or worse outcome over two years were identified.

Original languageEnglish (US)
Pages (from-to)204-211
Number of pages8
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume20
Issue number3
StatePublished - Oct 2003

Fingerprint

Sarcoidosis
Dyspnea
Thorax
African Americans
Erythema Nodosum
Lung
Population

Keywords

  • Chest radiograph
  • Dyspnea
  • Prognosis
  • Sarcoidosis
  • Spirometry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Judson, M. A., Baughman, R. P., Thompson, B. W., Teirstein, A. S., Terrin, M. L., Rossman, M. D., ... Cherniak, R. (2003). Two year prognosis of sarcoidosis: The ACCESS experience. Sarcoidosis Vasculitis and Diffuse Lung Diseases, 20(3), 204-211.

Two year prognosis of sarcoidosis : The ACCESS experience. / Judson, Marc A.; Baughman, Robert P.; Thompson, Bruce W.; Teirstein, Alvin S.; Terrin, Michael L.; Rossman, Milton D.; Yeager, Henry; McLennan, Geoffrey; Bresnitz, Eddy A.; DePalo, Louis; Hunninghake, Gary; Iannuzzi, Michael C.; Johns, Carol J.; Moller, David; Newman, Lee S.; Rabin, David L.; Rose, Cecile; Rybicki, Benjamin A.; Weinberger, Steven E.; Knatterud, Genell L.; Cherniak, Reuben.

In: Sarcoidosis Vasculitis and Diffuse Lung Diseases, Vol. 20, No. 3, 10.2003, p. 204-211.

Research output: Contribution to journalArticle

Judson, MA, Baughman, RP, Thompson, BW, Teirstein, AS, Terrin, ML, Rossman, MD, Yeager, H, McLennan, G, Bresnitz, EA, DePalo, L, Hunninghake, G, Iannuzzi, MC, Johns, CJ, Moller, D, Newman, LS, Rabin, DL, Rose, C, Rybicki, BA, Weinberger, SE, Knatterud, GL & Cherniak, R 2003, 'Two year prognosis of sarcoidosis: The ACCESS experience', Sarcoidosis Vasculitis and Diffuse Lung Diseases, vol. 20, no. 3, pp. 204-211.
Judson MA, Baughman RP, Thompson BW, Teirstein AS, Terrin ML, Rossman MD et al. Two year prognosis of sarcoidosis: The ACCESS experience. Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2003 Oct;20(3):204-211.
Judson, Marc A. ; Baughman, Robert P. ; Thompson, Bruce W. ; Teirstein, Alvin S. ; Terrin, Michael L. ; Rossman, Milton D. ; Yeager, Henry ; McLennan, Geoffrey ; Bresnitz, Eddy A. ; DePalo, Louis ; Hunninghake, Gary ; Iannuzzi, Michael C. ; Johns, Carol J. ; Moller, David ; Newman, Lee S. ; Rabin, David L. ; Rose, Cecile ; Rybicki, Benjamin A. ; Weinberger, Steven E. ; Knatterud, Genell L. ; Cherniak, Reuben. / Two year prognosis of sarcoidosis : The ACCESS experience. In: Sarcoidosis Vasculitis and Diffuse Lung Diseases. 2003 ; Vol. 20, No. 3. pp. 204-211.
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