Two-year longitudinal study of post-stroke mood disorders: Dynamic changes in correlates of depression at one and two years

Rajesh M. Parikh, John R Lipsey, Robert G. Robinson, Thomas R. Price

Research output: Contribution to journalArticle

Abstract

As part of a prospective study of 103 stroke patients, we have analyzed the relation between depression and associated variables at 3 months, 6 months, 1 year, and 2 years after stroke. At all intervals up to and including 1 year poststroke, patients with left hemisphere strokes showed a strong relation between severity of depression and distance of the lesion on computed tomography scan from the frontal pole. At 2years poststroke, this relation was no longer significant. The correlation between depression and impairment in activities of dairy living peaked at 6 months and thereafter fell but remained significant at 1 and 2 years poststroke. The correlation between depression and cognitive impairment and between depression and social functioning fluctuated—with most correlations at 1 and 2 years follow-up nonsignificant. Although the conclusions that can be drawn from this study are limited by the fact that less than half of the original patients were followed up at each time, these declining correlations between depression and associated variables at 1 and 2years follow-up may reflect the natural course of major depression which spontaneously remits between 1 and 2 years after stroke. The persisting significant association of impairment in activities of daily living with depression may reflect the effect of severe depression in sustaining and possibly retarding recovery from physical impairment.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalStroke
Volume18
Issue number3
StatePublished - 1987
Externally publishedYes

Fingerprint

Mood Disorders
Longitudinal Studies
Stroke
Depression
Activities of Daily Living
Tomography
Prospective Studies

Keywords

  • Brain injury
  • Depression
  • Longitudinal
  • Outcome
  • Prognosis
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing
  • Neuroscience(all)

Cite this

Two-year longitudinal study of post-stroke mood disorders : Dynamic changes in correlates of depression at one and two years. / Parikh, Rajesh M.; Lipsey, John R; Robinson, Robert G.; Price, Thomas R.

In: Stroke, Vol. 18, No. 3, 1987, p. 579-584.

Research output: Contribution to journalArticle

Parikh, Rajesh M. ; Lipsey, John R ; Robinson, Robert G. ; Price, Thomas R. / Two-year longitudinal study of post-stroke mood disorders : Dynamic changes in correlates of depression at one and two years. In: Stroke. 1987 ; Vol. 18, No. 3. pp. 579-584.
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