Two-year follow-up of a 6-month randomized trial of atropine vs patching for treatment of moderate amblyopia in children

Michael X Repka, David K. Wallace, Roy W. Beck, Raymond T. Kraker, Eileen E. Birch, Susan A. Cotter, Sean Donahue, Donald F. Everett, Richard W. Hertle, Jonathan M. Holmes, Graham E. Quinn, Mitchell M. Scheiman, David R. Weakley

Research output: Contribution to journalArticle

Abstract

Objective: To compare patching and atropine sulfate as treatments for moderate amblyopia in children 18 months after completion of a 6-month randomized trial. Methods: In a randomized, multicenter (47 sites) clinical trial, 419 children younger than 7 years with amblyopia (20/40 to 20/100 in the affected eye) were assigned to receive either patching or atropine eye drops for 6 months. Between 6 months and 2 years, treatment was at the discretion of the investigator. Main Outcome Measure: Visual acuity in the amblyopic eye and sound eye after 2 years. Results: At 2 years, visual acuity in the amblyopic eye improved from baseline a mean of 3.7 lines in the patching group and 3.6 lines in the atropine group. The difference in visual acuity between treatment groups was small: 0.01 logMAR (95% confidence interval, -0.02 to 0.04). In both treatment groups, the mean amblyopic eye acuity was approximately 20/32, 1.8 lines worse than the mean sound eye acuity, which was approximately 20/20. Conclusions: Atropine or patching for 6 months followed by best clinical care until 2 years produced similar improvement of moderate amblyopia in children between 3 and 7 years of age at enrollment. However, on average the amblyopic eye acuity was still approximately 2 lines worse than the sound eye.

Original languageEnglish (US)
Pages (from-to)149-157
Number of pages9
JournalArchives of Ophthalmology
Volume123
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

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Amblyopia
Atropine
Visual Acuity
Therapeutics
Ophthalmic Solutions
Research Personnel
Outcome Assessment (Health Care)
Clinical Trials
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Two-year follow-up of a 6-month randomized trial of atropine vs patching for treatment of moderate amblyopia in children. / Repka, Michael X; Wallace, David K.; Beck, Roy W.; Kraker, Raymond T.; Birch, Eileen E.; Cotter, Susan A.; Donahue, Sean; Everett, Donald F.; Hertle, Richard W.; Holmes, Jonathan M.; Quinn, Graham E.; Scheiman, Mitchell M.; Weakley, David R.

In: Archives of Ophthalmology, Vol. 123, No. 2, 02.2005, p. 149-157.

Research output: Contribution to journalArticle

Repka, MX, Wallace, DK, Beck, RW, Kraker, RT, Birch, EE, Cotter, SA, Donahue, S, Everett, DF, Hertle, RW, Holmes, JM, Quinn, GE, Scheiman, MM & Weakley, DR 2005, 'Two-year follow-up of a 6-month randomized trial of atropine vs patching for treatment of moderate amblyopia in children', Archives of Ophthalmology, vol. 123, no. 2, pp. 149-157. https://doi.org/10.1001/archopht.123.2.149
Repka, Michael X ; Wallace, David K. ; Beck, Roy W. ; Kraker, Raymond T. ; Birch, Eileen E. ; Cotter, Susan A. ; Donahue, Sean ; Everett, Donald F. ; Hertle, Richard W. ; Holmes, Jonathan M. ; Quinn, Graham E. ; Scheiman, Mitchell M. ; Weakley, David R. / Two-year follow-up of a 6-month randomized trial of atropine vs patching for treatment of moderate amblyopia in children. In: Archives of Ophthalmology. 2005 ; Vol. 123, No. 2. pp. 149-157.
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