Abstract
Objective: The purpose was to determine whether preeclampsia (PE) is caused by microfragments of syncytial trophoblast shed into the maternal circulation that stimulate an exaggerated inflammatory response. Study design: A nested case control study was performed within the Calcium for Preeclampsia Prevention trial cohort of healthy nulliparous women. Each preeclampsia case was matched to 1 normotensive control. One hundred twenty pairs were randomly chosen for analysis of serum cell-free fetal DNA (cffDNA), a marker of placental debris, and C-reactive protein (CRP), a marker of inflammation, in all 658 specimens obtained before labor. Results: At 29 to 41 weeks of gestation, cffDNA concentrations were significantly higher after preeclampsia than before (219 vs 112 genome equivalents [GE]/mL, P
Original language | English (US) |
---|---|
Pages (from-to) | 707-713 |
Number of pages | 7 |
Journal | American Journal of Obstetrics and Gynecology |
Volume | 190 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2004 |
Externally published | Yes |
Keywords
- C-reactive protein
- Cell-free fetal DNA
- Inflammation
- Placenta
- Preeclampsia
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology