Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia

Richard J. Levine, Cong Qian, Erik S. Leshane, Kai F. Yu, Lucinda J. England, Enrique F. Schisterman, Tuangsit Wataganara, Roberto Romero, Diana W. Bianchi

Research output: Contribution to journalArticlepeer-review


Objective: The purpose was to determine whether preeclampsia (PE) is caused by microfragments of syncytial trophoblast shed into the maternal circulation that stimulate an exaggerated inflammatory response. Study design: A nested case control study was performed within the Calcium for Preeclampsia Prevention trial cohort of healthy nulliparous women. Each preeclampsia case was matched to 1 normotensive control. One hundred twenty pairs were randomly chosen for analysis of serum cell-free fetal DNA (cffDNA), a marker of placental debris, and C-reactive protein (CRP), a marker of inflammation, in all 658 specimens obtained before labor. Results: At 29 to 41 weeks of gestation, cffDNA concentrations were significantly higher after preeclampsia than before (219 vs 112 genome equivalents [GE]/mL, P

Original languageEnglish (US)
Pages (from-to)707-713
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Issue number3
StatePublished - Mar 2004
Externally publishedYes


  • C-reactive protein
  • Cell-free fetal DNA
  • Inflammation
  • Placenta
  • Preeclampsia

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology


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