Two rat homologs of clathrin-associated adaptor proteins

Jonathan Pevsner, Walter Volknandt, Brian R. Wong, Richard H. Scheller

Research output: Contribution to journalArticlepeer-review


A cDNA clone predicted to encode a 46 757-Da protein was isolated from a library derived from the electric lobe of the ray Discopyge ommata. Two rat homologs, p47A and p47B, were subsequently isolated. These three proteins share approx. 80% amino acid (aa) identity to each other and have 27-30% aa identity to rat AP50 and mouse AP47, the medium-chain subunits of adaptor complexes associated with clathrin-coated vesicles. These complexes are involved in receptor-mediated pathways of intracellular transport. Rat p47A mRNA is expressed in all tissues examined, including brain, heart, kidney, liver, lung, muscle and spinal cord. Rat p47B mRNA is detected exclusively in brain and spinal cord, and may participate in nervous system-specific functions such as biogenesis or recycling of synaptic vesicles.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
Issue number2
StatePublished - Sep 2 1994
Externally publishedYes


  • Assembly proteins
  • membrane trafficking
  • ray electric lobe
  • recycling
  • vesicles

ASJC Scopus subject areas

  • Genetics


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