Two-phase [11C]l-methionine PET in childhood brain tumors

Lorcan A. O'Tuama, Peter C. Phillips, Lewis C. Strauss, Benjamin Solomon, Yoshihiro Uno, Quentin R. Smith, Robert F Dannals, Alan A. Wilson, Hayden T. Ravert, Sandra Loats, Harry A. Loats, Norman D. LaFrance, Henry N. Wagner

Research output: Contribution to journalArticle

Abstract

Thirteen children (1.8-15.8 years of age) with brain tumors were studied with [11C]l-methionine positron emission tomography (METPET). Patients were injected intravenously with tracer before a baseline PET scan was obtained. To assess the sensitivity of [11C]l-methionine uptake to competitive inhibition, 10 patients received oral l-phenylalanine (100 mg/kg); 1 hour later, a second METPET was obtained. Subjective assessment of [11C]l-methionine uptake closely paralleled results of quantitative examination (r = 0.81). [11C]l-methionine uptake in tumor-containing brain was increased in 11 patients (mean ratio of [11C] radioactivity in tumor to normal brain: 1.5 ± 0.57; range: 1.13-2.98). Increased tracer uptake occurred in ependymomas (3), medulloblastoma (1), and astrocytomas (5), but was less intense in low-grade tumors. l-phenylalanine reduced l-methionine uptake (25-69%) in 70% of studies. l-methionine uptake was not sensitive to competitive inhibition in brain radiation injury. Two-phase METPET is of potential value in difficult clinical situations evident in children with brain tumors, including the differential diagnosis of tumor recurrence and cerebral radiation injury.

Original languageEnglish (US)
Pages (from-to)163-170
Number of pages8
JournalPediatric Neurology
Volume6
Issue number3
DOIs
StatePublished - 1990

Fingerprint

Brain Neoplasms
Methionine
Positron-Emission Tomography
Radiation Injuries
Phenylalanine
Ependymoma
Neoplasms
Medulloblastoma
Astrocytoma
Brain Injuries
Radioactivity
Differential Diagnosis
Recurrence
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

O'Tuama, L. A., Phillips, P. C., Strauss, L. C., Solomon, B., Uno, Y., Smith, Q. R., ... Wagner, H. N. (1990). Two-phase [11C]l-methionine PET in childhood brain tumors. Pediatric Neurology, 6(3), 163-170. https://doi.org/10.1016/0887-8994(90)90057-8

Two-phase [11C]l-methionine PET in childhood brain tumors. / O'Tuama, Lorcan A.; Phillips, Peter C.; Strauss, Lewis C.; Solomon, Benjamin; Uno, Yoshihiro; Smith, Quentin R.; Dannals, Robert F; Wilson, Alan A.; Ravert, Hayden T.; Loats, Sandra; Loats, Harry A.; LaFrance, Norman D.; Wagner, Henry N.

In: Pediatric Neurology, Vol. 6, No. 3, 1990, p. 163-170.

Research output: Contribution to journalArticle

O'Tuama, LA, Phillips, PC, Strauss, LC, Solomon, B, Uno, Y, Smith, QR, Dannals, RF, Wilson, AA, Ravert, HT, Loats, S, Loats, HA, LaFrance, ND & Wagner, HN 1990, 'Two-phase [11C]l-methionine PET in childhood brain tumors', Pediatric Neurology, vol. 6, no. 3, pp. 163-170. https://doi.org/10.1016/0887-8994(90)90057-8
O'Tuama, Lorcan A. ; Phillips, Peter C. ; Strauss, Lewis C. ; Solomon, Benjamin ; Uno, Yoshihiro ; Smith, Quentin R. ; Dannals, Robert F ; Wilson, Alan A. ; Ravert, Hayden T. ; Loats, Sandra ; Loats, Harry A. ; LaFrance, Norman D. ; Wagner, Henry N. / Two-phase [11C]l-methionine PET in childhood brain tumors. In: Pediatric Neurology. 1990 ; Vol. 6, No. 3. pp. 163-170.
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