TY - JOUR
T1 - Two novel mutations of the nicastrin gene in Chinese patients with acne inversa
AU - Li, C. R.
AU - Jiang, M. J.
AU - Shen, D. B.
AU - Xu, H. X.
AU - Wang, H. S.
AU - Yao, X.
AU - Zhang, Y.
AU - Zhou, W. Q.
AU - Wang, B.
PY - 2011/8
Y1 - 2011/8
N2 - Acne inversa (AI, OMIM 142690), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent and debilitating skin follicular disease that usually presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body, most commonly the axilla, inguinal and anogenital regions. The prevalence of AI has been estimated at 1 in 100 to 1 in 600. Of patients with AI, 35-40% have a positive family history. The pattern of transmission is consistent with autosomal dominant inheritance. In 2006, Gao et al. mapped the AI gene at chromosome 1p21.1-1q25.3. In 2010, Wang et al. were the first to identify mutations of γ-secretase genes responsible for AI among six Chinese families. γ-Secretase is a transmembrane protease composed of four essential protein subunits: one catalytic presenilin (PSEN1) subunit and three cofactor subunits [presenilin enhancer 2 (PSENEN), nicastrin (NCSTN) and anterior pharynx defective 1 (APH1)]. Two, one and three mutations were found in PSENEN, PSEN1 and NCSTN, respectively. Here, we report a heterozygous nonsense c.1695T>G mutation and a heterozygous missense c.632C>G mutation of the NCSTN gene in two Chinese AI families.
AB - Acne inversa (AI, OMIM 142690), also called hidradenitis suppurativa, is a chronic, inflammatory, recurrent and debilitating skin follicular disease that usually presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body, most commonly the axilla, inguinal and anogenital regions. The prevalence of AI has been estimated at 1 in 100 to 1 in 600. Of patients with AI, 35-40% have a positive family history. The pattern of transmission is consistent with autosomal dominant inheritance. In 2006, Gao et al. mapped the AI gene at chromosome 1p21.1-1q25.3. In 2010, Wang et al. were the first to identify mutations of γ-secretase genes responsible for AI among six Chinese families. γ-Secretase is a transmembrane protease composed of four essential protein subunits: one catalytic presenilin (PSEN1) subunit and three cofactor subunits [presenilin enhancer 2 (PSENEN), nicastrin (NCSTN) and anterior pharynx defective 1 (APH1)]. Two, one and three mutations were found in PSENEN, PSEN1 and NCSTN, respectively. Here, we report a heterozygous nonsense c.1695T>G mutation and a heterozygous missense c.632C>G mutation of the NCSTN gene in two Chinese AI families.
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U2 - 10.1111/j.1365-2133.2011.10372.x
DO - 10.1111/j.1365-2133.2011.10372.x
M3 - Article
C2 - 21495993
AN - SCOPUS:79960652604
SN - 0007-0963
VL - 165
SP - 415
EP - 418
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 2
ER -