Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting

Maxwell P. Lee, Sheri Brandenburg, Gregory M. Landes, Mark Adams, Glenn Miller, Andrew P Feinberg

Research output: Contribution to journalArticle

Abstract

We previously reported the isolation of a 2.5 Mb tumor-suppressing subchromosomal transferable fragment (STF) from human chromosome 11p15 and the identification of nine known genes and four novel genes within this STF. We now report the isolation of two novel cDNAs, designated here as TSSC4 and TSSC6 (tumor-suppressing STF cDNA 4 and 6), located within the STF, TSSC4 and TSSC6 encode predicted proteins of 329 and 290 amino acids, respectively, with no close similarity to previously reported proteins. TSSC4 and TSSC6 are both located in the center of a 1 Mb imprinted domain, which contains the imprinted genes TSSC3, TSSC5, p57(KIP2), K(V)LQT1, ASCL2, IGF2 and H19. However, we found that neither TSSC4 nor TSSC6 was significantly imprinted in any of the fetal or extra-embryonic tissues examined. Based on this result, the imprinted gene domain of 11p15 appears to contain at least two imprinted subdomains, between which TSSC4 and TSSC6 substantially escape imprinting, due either to lack of initial silencing or to an early developmental relaxation of imprinting.

Original languageEnglish (US)
Pages (from-to)683-690
Number of pages8
JournalHuman Molecular Genetics
Volume8
Issue number4
StatePublished - 1999

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Genomic Imprinting
Complementary DNA
Genes
Neoplasms
Human Chromosomes
Proteins
Amino Acids

ASJC Scopus subject areas

  • Genetics

Cite this

Lee, M. P., Brandenburg, S., Landes, G. M., Adams, M., Miller, G., & Feinberg, A. P. (1999). Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. Human Molecular Genetics, 8(4), 683-690.

Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. / Lee, Maxwell P.; Brandenburg, Sheri; Landes, Gregory M.; Adams, Mark; Miller, Glenn; Feinberg, Andrew P.

In: Human Molecular Genetics, Vol. 8, No. 4, 1999, p. 683-690.

Research output: Contribution to journalArticle

Lee, MP, Brandenburg, S, Landes, GM, Adams, M, Miller, G & Feinberg, AP 1999, 'Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting', Human Molecular Genetics, vol. 8, no. 4, pp. 683-690.
Lee, Maxwell P. ; Brandenburg, Sheri ; Landes, Gregory M. ; Adams, Mark ; Miller, Glenn ; Feinberg, Andrew P. / Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting. In: Human Molecular Genetics. 1999 ; Vol. 8, No. 4. pp. 683-690.
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