Two molecular transitions influence cardiac sodium channel gating

David T. Yue, John H. Lawrence, Eduardo Marban

Research output: Contribution to journalArticlepeer-review

Abstract

Sodium channels from diverse excitable membranes are very similar in their structure, yet surprisingly heterogeneous in their behavior. The processes that govern the opening and closing of sodium channels have appeared difficult to describe in terms of a single, unifying molecular scheme. Now cardiac sodium channels have been analyzed by high-resolution single-channel recordings over a broad range of potentials. Channels exhibited both complex and simple gating patterns at different voltages. Such behavioral diversity can be explained by the balance between two molecular transitions whereby channels can exit the open state.

Original languageEnglish (US)
Pages (from-to)349-352
Number of pages4
JournalScience
Volume244
Issue number4902
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • General

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