Two mechanisms for escape from immune surveillance by neurotropic retroviruses

Janice E Clements, Opendra Narayan

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The mechanism(s) by which lentiviruses and related non‐oncogenic retroviruses (e.g. HTLV‐III, the etiologic agent of AIDS) escape immune surveillance, and thereby create long term progressive disease conditions, has been unknown until recently. Studies with two lentiviruses have begun to illuminate the mechanisms. In one, antigenic drift in the virus appears to be the primary mechanism of escape from immune surveillance; in the second, selective masking of the viral envelope glycoprotein epitope, which normally elicits neutralizing anti‐body, appears to provide the means of escape.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
Issue number6
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Two mechanisms for escape from immune surveillance by neurotropic retroviruses'. Together they form a unique fingerprint.

Cite this