Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP

David Duggan, Siqun L. Zheng, Michele Knowlton, Debbie Benitez, Latchezar Dimitrov, Fredrik Wiklund, Christiane Robbins, Sarah D. Isaacs, Yu Cheng, Ge Li, Jielin Sun, Bao Li Chang, Leslie Marovich, Kathleen E. Wiley, Katarina Bälter, Pär Stattin, Hans Olov Adami, Marta Gielzak, Guifang Yan, Jurga Sauvageot & 11 others Wennuan Liu, Jin Woo Kim, Eugene R. Bleecker, Deborah A. Meyers, Bruce Trock, Alan Wayne Partin, Patrick Walsh, William B Isaacs, Henrik Grönberg, Jianfeng Xu, John D. Carpten

Research output: Contribution to journalArticle

Abstract

Background: The consistent finding of a genetic susceptibility to prostate cancer suggests that there are germline sequence variants predisposing individuals to this disease. These variants could be useful in screening and treatment. Methods: We performed an exploratory genome-wide association scan in 498 men with aggressive prostate cancer and 494 control subjects selected from a population-based case-control study in Sweden. We combined the results of this scan with those for aggressive prostate cancer from the publicly available Cancer Genetic Markers of Susceptibility (CGEMS) Study. Single-nucleotide polymorphisms (SNPs) that showed statistically significant associations with the risk of aggressive prostate cancer based on two-sided allele tests were tested for their association with aggressive prostate cancer in two independent study populations composed of individuals of European or African American descent using one-sided tests and the genetic model (dominant or additive) associated with the lowest value in the exploratory study. Results: Among the approximately 60000 SNPs that were common to our study and CGEMS, we identified seven that had a similar (positive or negative) and statistically significant (P

Original languageEnglish (US)
Pages (from-to)1836-1844
Number of pages9
JournalJournal of the National Cancer Institute
Volume99
Issue number24
DOIs
StatePublished - Dec 2007

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Genome-Wide Association Study
Tumor Suppressor Genes
Prostate
Prostatic Neoplasms
Genetic Predisposition to Disease
Genetic Markers
Single Nucleotide Polymorphism
Genetic Models
Sweden
African Americans
Population
Case-Control Studies
Neoplasms
Alleles

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP. / Duggan, David; Zheng, Siqun L.; Knowlton, Michele; Benitez, Debbie; Dimitrov, Latchezar; Wiklund, Fredrik; Robbins, Christiane; Isaacs, Sarah D.; Cheng, Yu; Li, Ge; Sun, Jielin; Chang, Bao Li; Marovich, Leslie; Wiley, Kathleen E.; Bälter, Katarina; Stattin, Pär; Adami, Hans Olov; Gielzak, Marta; Yan, Guifang; Sauvageot, Jurga; Liu, Wennuan; Kim, Jin Woo; Bleecker, Eugene R.; Meyers, Deborah A.; Trock, Bruce; Partin, Alan Wayne; Walsh, Patrick; Isaacs, William B; Grönberg, Henrik; Xu, Jianfeng; Carpten, John D.

In: Journal of the National Cancer Institute, Vol. 99, No. 24, 12.2007, p. 1836-1844.

Research output: Contribution to journalArticle

Duggan, D, Zheng, SL, Knowlton, M, Benitez, D, Dimitrov, L, Wiklund, F, Robbins, C, Isaacs, SD, Cheng, Y, Li, G, Sun, J, Chang, BL, Marovich, L, Wiley, KE, Bälter, K, Stattin, P, Adami, HO, Gielzak, M, Yan, G, Sauvageot, J, Liu, W, Kim, JW, Bleecker, ER, Meyers, DA, Trock, B, Partin, AW, Walsh, P, Isaacs, WB, Grönberg, H, Xu, J & Carpten, JD 2007, 'Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP', Journal of the National Cancer Institute, vol. 99, no. 24, pp. 1836-1844. https://doi.org/10.1093/jnci/djm250
Duggan, David ; Zheng, Siqun L. ; Knowlton, Michele ; Benitez, Debbie ; Dimitrov, Latchezar ; Wiklund, Fredrik ; Robbins, Christiane ; Isaacs, Sarah D. ; Cheng, Yu ; Li, Ge ; Sun, Jielin ; Chang, Bao Li ; Marovich, Leslie ; Wiley, Kathleen E. ; Bälter, Katarina ; Stattin, Pär ; Adami, Hans Olov ; Gielzak, Marta ; Yan, Guifang ; Sauvageot, Jurga ; Liu, Wennuan ; Kim, Jin Woo ; Bleecker, Eugene R. ; Meyers, Deborah A. ; Trock, Bruce ; Partin, Alan Wayne ; Walsh, Patrick ; Isaacs, William B ; Grönberg, Henrik ; Xu, Jianfeng ; Carpten, John D. / Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP. In: Journal of the National Cancer Institute. 2007 ; Vol. 99, No. 24. pp. 1836-1844.
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AU - Knowlton, Michele

AU - Benitez, Debbie

AU - Dimitrov, Latchezar

AU - Wiklund, Fredrik

AU - Robbins, Christiane

AU - Isaacs, Sarah D.

AU - Cheng, Yu

AU - Li, Ge

AU - Sun, Jielin

AU - Chang, Bao Li

AU - Marovich, Leslie

AU - Wiley, Kathleen E.

AU - Bälter, Katarina

AU - Stattin, Pär

AU - Adami, Hans Olov

AU - Gielzak, Marta

AU - Yan, Guifang

AU - Sauvageot, Jurga

AU - Liu, Wennuan

AU - Kim, Jin Woo

AU - Bleecker, Eugene R.

AU - Meyers, Deborah A.

AU - Trock, Bruce

AU - Partin, Alan Wayne

AU - Walsh, Patrick

AU - Isaacs, William B

AU - Grönberg, Henrik

AU - Xu, Jianfeng

AU - Carpten, John D.

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