TY - JOUR
T1 - Two distinct central serotonin receptors with different physiological functions
AU - Peroutka, Stephen J.
AU - Lebovitz, Richard M.
AU - Snyder, Solomon H.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synoptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.
AB - Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synoptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.
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U2 - 10.1126/science.7221567
DO - 10.1126/science.7221567
M3 - Article
C2 - 7221567
AN - SCOPUS:0019793815
SN - 0036-8075
VL - 212
SP - 827
EP - 829
JO - Science
JF - Science
IS - 4496
ER -