Two distinct central serotonin receptors with different physiological functions

Stephen J. Peroutka, Richard M. Lebovitz, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synoptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.

Original languageEnglish (US)
Pages (from-to)827-829
Number of pages3
JournalScience
Volume212
Issue number4496
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • General

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