TY - JOUR
T1 - Two-dimensional strain profiles in patients with physiological and pathological hypertrophy and preserved left ventricular systolic function
T2 - A comparative analyses
AU - Afonso, Luis
AU - Kondur, Ashok
AU - Simegn, Mengistu
AU - Niraj, Ashutosh
AU - Hari, Pawan
AU - Kaur, Ramanjit
AU - Ramappa, Preeti
AU - Pradhan, Jyotiranjan
AU - Bhandare, Deepti
AU - Williams, Kim A.
AU - Zalawadiya, Sandip
AU - Pinheiro, Aurelio
AU - Abraham, Theodore P.
PY - 2012
Y1 - 2012
N2 - Objective: This study was designed to examine the utility of two-dimensional strain (2DS) or speckle tracking imaging to typify functional adaptations of the left ventricle in variant forms of left ventricular hypertrophy (LVH). Design: Cross-sectional study. Setting: Urban tertiary care academic medical centres. Participants: A total of 129 subjects, 56 with hypertrophic cardiomyopathy (HCM), 34 with hypertensive left ventricular hypertrophy (H-LVH), 27 professional athletes with LVH (AT-LVH) and 12 healthy controls in sinus rhythm with preserved left ventricular systolic function. Methods: Conventional echocardiographic and tissue Doppler examinations were performed in all study subjects. Bi-dimensional acquisitions were analysed to map longitudinal systolic strain (automated function imaging, AFI, GE Healthcare, Waukesha, Wisconsin, USA) from apical views. Results: Subjects with HCM had significantly lower regional and average global peak longitudinal systolic strain (GLS-avg) compared with controls and other forms of LVH. Strain dispersion index, a measure of regional contractile heterogeneity, was higher in HCM compared with the rest of the groups. On receiver operator characteristics analysis, GLS-avg had excellent discriminatory ability to distinguish HCM from H-LVH area under curve (AUC) (0.893, p<0.001) or AT-LVH AUC (0.920, p<<0.001). Tissue Doppler and LV morphological parameters were better suited to differentiate the athlete heart from HCM. Conclusions: 2DS (AFI) allows rapid characterisation of regional and global systolic function and may have the potential to differentiate HCM from variant forms of LVH.
AB - Objective: This study was designed to examine the utility of two-dimensional strain (2DS) or speckle tracking imaging to typify functional adaptations of the left ventricle in variant forms of left ventricular hypertrophy (LVH). Design: Cross-sectional study. Setting: Urban tertiary care academic medical centres. Participants: A total of 129 subjects, 56 with hypertrophic cardiomyopathy (HCM), 34 with hypertensive left ventricular hypertrophy (H-LVH), 27 professional athletes with LVH (AT-LVH) and 12 healthy controls in sinus rhythm with preserved left ventricular systolic function. Methods: Conventional echocardiographic and tissue Doppler examinations were performed in all study subjects. Bi-dimensional acquisitions were analysed to map longitudinal systolic strain (automated function imaging, AFI, GE Healthcare, Waukesha, Wisconsin, USA) from apical views. Results: Subjects with HCM had significantly lower regional and average global peak longitudinal systolic strain (GLS-avg) compared with controls and other forms of LVH. Strain dispersion index, a measure of regional contractile heterogeneity, was higher in HCM compared with the rest of the groups. On receiver operator characteristics analysis, GLS-avg had excellent discriminatory ability to distinguish HCM from H-LVH area under curve (AUC) (0.893, p<0.001) or AT-LVH AUC (0.920, p<<0.001). Tissue Doppler and LV morphological parameters were better suited to differentiate the athlete heart from HCM. Conclusions: 2DS (AFI) allows rapid characterisation of regional and global systolic function and may have the potential to differentiate HCM from variant forms of LVH.
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U2 - 10.1136/bmjopen-2012-001390
DO - 10.1136/bmjopen-2012-001390
M3 - Article
C2 - 22904333
AN - SCOPUS:84865981296
SN - 2044-6055
VL - 2
JO - BMJ open
JF - BMJ open
IS - 4
M1 - e001390
ER -