Two-dimensional echocardiography in dogs. Variation of left ventricular mass, geometry, volume, and ejection fraction on cardiopulmonary bypass

G. B. Haasler, P. C. Rodigas, R. H. Collins, J. Wei, F. J. Meyer, A. J. Spotnitz, H. M. Spotnitz

Research output: Contribution to journalArticlepeer-review

Abstract

Quantitative two-dimensional echocardiography was evaluated in 39 open-chest dogs placed on cardiopulmonary bypass. The correlation coefficient of left ventricular end-diastolic volume against postmortem pressure-volume curves was r = 0.89 to 0.93 (347 measurements in 15 dogs, 0 to 24 mm Hg). Ejection fraction was validated against roller pump flow and echo left ventricular end-diastolic volume (r=0.83, n=13). Left ventricular mass in vivo was compared with postmortem left ventricular mass (r=0.81 in 21 early studies, r=0.91 in 10 later studies with updated equipment) and was found to increase with ischemic injury as well as cardiopulmonary bypass with hemodilution. Left ventricular mass increased (p<0.001) from 119 ± 5 (standard error of the mean) to 138 ± 6 gm (n=23) after 2 1/2 hours on cardiopulmonary bypass and moderate hemodilution. With the addition of ischemic arrest, left ventricular mass increased from 119 ± 7 to 148 ± 11 gm (p<0.01, n=8), and myocardial water content increased by 2.0% ± 0.4%, which accounted for at least 65% of the observed mass change. Mean left ventricular wall thickness increased from 13.8 to 15.5 mm (p=0.02) after ischemia. Ventricular shape became more spherical with increasing left ventricular end-diastolic pressure. We conclude that two-dimensional echocardiography can be reliably used for accurate, serial measurements in physiological studies. The demonstrated variability in left ventricular mass is important, yet frequently ignored. Recognizing left ventricular mass changes may facilitate the detection of myocardial injury reflected as edema.

Original languageEnglish (US)
Pages (from-to)430-440
Number of pages11
JournalJournal of Thoracic and Cardiovascular Surgery
Volume90
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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