Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities

Stewart H Hendry, E. G. Jones, P. C. Emson, D. E M Lawson, C. W. Heizmann, P. Streit

Research output: Contribution to journalArticle

Abstract

Calcium ions play a key role in many aspects of neuronal behavior and certain calcium binding proteins that may influence this behavior are differentially distributed in the central nervous system. In this study it is shown that immunoreactivity for calbindin-28 and for parvalbumin is localized in separate populations of inhibitory GABA interneurons in all areas of the neocortex of Old World monkeys. Virtually all GABA neurosn show immunoreactivity for one or other calcium binding protein but, except for a few cells in layer IV, GABA cells do not show immunoreactivity for both proteins. Among the two cell populations, parvalbumin immunoreactivity characterizes basket neurons while calbindin immunoreactivity characterizes double bouquet neurons. These findings suggest that the two GABA cell types differ in their regulation of calcium homeostasis and may yield clues to their different roles in intracortical circuitry.

Original languageEnglish (US)
Pages (from-to)467-472
Number of pages6
JournalExperimental Brain Research
Volume76
Issue number2
DOIs
StatePublished - Jul 1989
Externally publishedYes

Fingerprint

Calbindins
GABAergic Neurons
Parvalbumins
Calcium-Binding Proteins
gamma-Aminobutyric Acid
Cercopithecidae
Calcium
Neurons
Neocortex
Interneurons
Population
Homeostasis
Central Nervous System
Ions
Proteins

Keywords

  • Calbindin
  • Cerebral cortex
  • GABA neurons
  • Monkey
  • Parvalbumin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities. / Hendry, Stewart H; Jones, E. G.; Emson, P. C.; Lawson, D. E M; Heizmann, C. W.; Streit, P.

In: Experimental Brain Research, Vol. 76, No. 2, 07.1989, p. 467-472.

Research output: Contribution to journalArticle

Hendry, Stewart H ; Jones, E. G. ; Emson, P. C. ; Lawson, D. E M ; Heizmann, C. W. ; Streit, P. / Two classes of cortical GABA neurons defined by differential calcium binding protein immunoreactivities. In: Experimental Brain Research. 1989 ; Vol. 76, No. 2. pp. 467-472.
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