Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs

Junying Xu, Robert A. Ross, Richard W. McCallum, Jiande D.Z. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of the current study was to investigate the efficacy of 2-channel gastric electrical stimulation (GES) with a custom-made implantable pacemaker on delayed gastric emptying and gastric dysryhthmia induced by glucagon in dogs. Methods: Six dogs were studied in 4 randomized session (saline, glucagon, glucagon with single-channel or 2-channel GES). GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for 2-channel GES. Gastric emptying was assessed for 90 minutes and gastric slow waves were recorded at the same time. Results: Both single-channel and 2-channel GES improved gastric dysryhthmia (P < .05 vs glucagon session). Two-channel GES but not single-channel GES improved glucagon-induced delayed gastric emptying at 30 minutes, 45 minutes, 60 minutes, 75 minutes, and 90 minutes. Conclusion: Two-channel GES with a novel implantable pacemaker is more efficient and effective than single-channel GES in improving delayed gastric emptying induced by glucagon. This implantable multipoint pacemaker may provide a new option for treatment of gastric motility disorders.

Original languageEnglish (US)
Pages (from-to)122-129
Number of pages8
JournalAmerican journal of surgery
Volume195
Issue number1
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

Keywords

  • Gastric dysryhthmia
  • Gastric emptying
  • Gastric pacing
  • Gastroparesis
  • Implantable pacemaker

ASJC Scopus subject areas

  • Surgery

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