Two-channel gastric pacing in patients with diabetic gastroparesis

Zhiyue Lin, Irene Sarosiek, Jameson Forster, Robert A. Ross, Jiande Chen, Richard W. Mccallum

Research output: Contribution to journalArticle

Abstract

Background Our primary goals were to investigate the effects of two-channel gastric pacing on gastric myoelectrical activity, and energy consumption with the secondary intent to monitor gastric emptying and symptoms in patients with severe diabetic gastroparesis. Methods Four pairs of temporary pacing wires were inserted on the serosa of the stomach at the time of laparotomy to place the Enterra™ System in 19 patients with severe gastroparesis not responding to standard medical therapies. Two of the pairs were for electrical stimulation and the other two for recording. Five days after surgery the optimal pacing parameters for the entrainment of gastric slow waves in each patient were identified by serosal recordings. Two-channel gastric pacing was then initiated for 6weeks using a newly developed external multi-channel pulse generator. Electrogastrogram (EGG), Total Symptom Score (TSS), and a 4-h gastric emptying test were assessed at baseline and after 6weeks of active gastric pacing. Enterra™ device was turned OFF during the duration of this study. Key Results Two-channel gastric pacing at 1.1 times the intrinsic frequency entrained gastric slow waves and normalized gastric dysrhythmia. After 6weeks of gastric pacing, tachygastria was decreased from 15±3 to 5±1% in the fasting state and from 10±2 to 5±1% postprandially (P

Original languageEnglish (US)
JournalNeurogastroenterology and Motility
Volume23
Issue number10
DOIs
StatePublished - Oct 2011
Externally publishedYes

Fingerprint

Gastroparesis
Stomach
Gastric Emptying
Serous Membrane
Ambulatory Surgical Procedures
Laparotomy
Electric Stimulation
Fasting

Keywords

  • Gastric electrical stimulation
  • Gastric emptying
  • Gastric pacing
  • Gastric slow wave
  • Gastroparesis

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

Cite this

Two-channel gastric pacing in patients with diabetic gastroparesis. / Lin, Zhiyue; Sarosiek, Irene; Forster, Jameson; Ross, Robert A.; Chen, Jiande; Mccallum, Richard W.

In: Neurogastroenterology and Motility, Vol. 23, No. 10, 10.2011.

Research output: Contribution to journalArticle

Lin, Zhiyue ; Sarosiek, Irene ; Forster, Jameson ; Ross, Robert A. ; Chen, Jiande ; Mccallum, Richard W. / Two-channel gastric pacing in patients with diabetic gastroparesis. In: Neurogastroenterology and Motility. 2011 ; Vol. 23, No. 10.
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