TY - JOUR
T1 - Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin
AU - Song, Gengqing
AU - Hou, Xiaohua
AU - Yang, Bin
AU - Liu, Jinsong
AU - Qian, Wei
AU - Chen, Jiande D.Z.
N1 - Funding Information:
This study was partially supported by a research grant from GI Stimulation Inc., Charlottesville, Virginia and American Diabetes Association.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/4
Y1 - 2005/4
N2 - The aim of this study was to investigate the effects of two-channel gastric electrical stimulation (GES) on delayed gastric emptying, gastric dysrhythmias, and motion sickness-like symptoms induced by vasopressin. Seven dogs implanted with four pairs of gastric electrodes and a duodenal cannula were studied in four randomized sessions (saline, vasopressin, single-channel GES, and two-channel GES). The experiment in each session was conducted sequentially as follows: 30-min baseline, ingestion of a liquid meal, 30-min iv infusion of vasopressin or saline, and two 30-min postprandial recordings. In the GES sessions, GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for two-channel GES. Gastric emptying was collected every 15 min via the cannula for a period of 90 min. Results were as follows. (1) Vasopressin induced gastric dysrhythmias, motion sickness-like symptoms, and delayed gastric emptying (P < 0.01, ANOVA). (2) GES normalized gastric dysrhythmias (P < 0.01) but showed no effects on vasopressin-induced emetic response. (3) Two-channel GES improved delayed gastric emptying induced by vasopressin. In comparison with the vasopressin session, two-channel GES, but not single-channel GES, significantly increased gastric emptying at 30 min (43.9 ± 12.6 vs. 27.5 ± 7.7%; P < 0.03), 60 min (75.3 ± 15.1 vs. 54.0 ± 17.8%; P < 0.05), and 90 min (91.6 ± 9.8 vs. 80.3 ± 9.0%; P < 0.05). GES with long pulses is able to normalize gastric dysrhythmias. Two-channel GES improves delayed gastric emptying induced by vasopressin.
AB - The aim of this study was to investigate the effects of two-channel gastric electrical stimulation (GES) on delayed gastric emptying, gastric dysrhythmias, and motion sickness-like symptoms induced by vasopressin. Seven dogs implanted with four pairs of gastric electrodes and a duodenal cannula were studied in four randomized sessions (saline, vasopressin, single-channel GES, and two-channel GES). The experiment in each session was conducted sequentially as follows: 30-min baseline, ingestion of a liquid meal, 30-min iv infusion of vasopressin or saline, and two 30-min postprandial recordings. In the GES sessions, GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for two-channel GES. Gastric emptying was collected every 15 min via the cannula for a period of 90 min. Results were as follows. (1) Vasopressin induced gastric dysrhythmias, motion sickness-like symptoms, and delayed gastric emptying (P < 0.01, ANOVA). (2) GES normalized gastric dysrhythmias (P < 0.01) but showed no effects on vasopressin-induced emetic response. (3) Two-channel GES improved delayed gastric emptying induced by vasopressin. In comparison with the vasopressin session, two-channel GES, but not single-channel GES, significantly increased gastric emptying at 30 min (43.9 ± 12.6 vs. 27.5 ± 7.7%; P < 0.03), 60 min (75.3 ± 15.1 vs. 54.0 ± 17.8%; P < 0.05), and 90 min (91.6 ± 9.8 vs. 80.3 ± 9.0%; P < 0.05). GES with long pulses is able to normalize gastric dysrhythmias. Two-channel GES improves delayed gastric emptying induced by vasopressin.
KW - Gastric dysrhythmia
KW - Gastric electrical stimulation
KW - Gastric emptying
KW - Gastric slow waves
KW - Gastrointestinal motility
KW - Symptoms
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U2 - 10.1007/s10620-005-2553-5
DO - 10.1007/s10620-005-2553-5
M3 - Article
C2 - 15844698
AN - SCOPUS:17644395992
SN - 0163-2116
VL - 50
SP - 662
EP - 668
JO - Digestive diseases and sciences
JF - Digestive diseases and sciences
IS - 4
ER -