Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin

Gengqing Song, Xiaohua Hou, Bin Yang, Jinsong Liu, Wei Qian, Jiande D.Z. Chen

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate the effects of two-channel gastric electrical stimulation (GES) on delayed gastric emptying, gastric dysrhythmias, and motion sickness-like symptoms induced by vasopressin. Seven dogs implanted with four pairs of gastric electrodes and a duodenal cannula were studied in four randomized sessions (saline, vasopressin, single-channel GES, and two-channel GES). The experiment in each session was conducted sequentially as follows: 30-min baseline, ingestion of a liquid meal, 30-min iv infusion of vasopressin or saline, and two 30-min postprandial recordings. In the GES sessions, GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for two-channel GES. Gastric emptying was collected every 15 min via the cannula for a period of 90 min. Results were as follows. (1) Vasopressin induced gastric dysrhythmias, motion sickness-like symptoms, and delayed gastric emptying (P < 0.01, ANOVA). (2) GES normalized gastric dysrhythmias (P < 0.01) but showed no effects on vasopressin-induced emetic response. (3) Two-channel GES improved delayed gastric emptying induced by vasopressin. In comparison with the vasopressin session, two-channel GES, but not single-channel GES, significantly increased gastric emptying at 30 min (43.9 ± 12.6 vs. 27.5 ± 7.7%; P < 0.03), 60 min (75.3 ± 15.1 vs. 54.0 ± 17.8%; P < 0.05), and 90 min (91.6 ± 9.8 vs. 80.3 ± 9.0%; P < 0.05). GES with long pulses is able to normalize gastric dysrhythmias. Two-channel GES improves delayed gastric emptying induced by vasopressin.

Original languageEnglish (US)
Pages (from-to)662-668
Number of pages7
JournalDigestive Diseases and Sciences
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

Keywords

  • Gastric dysrhythmia
  • Gastric electrical stimulation
  • Gastric emptying
  • Gastric slow waves
  • Gastrointestinal motility
  • Symptoms

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Two-channel gastric electrical stimulation accelerates delayed gastric emptying induced by vasopressin'. Together they form a unique fingerprint.

Cite this