Two Cases of Sinusitis Induced by Immune Checkpoint Inhibition

Research output: Contribution to journalArticle

Abstract

We report the acute onset of aseptic sinusitis in 2 patients receiving the immune checkpoint inhibitors, ipilimumab and nivolumab, for treatment of metastatic melanoma. Ipilimumab, a monoclonal antibody targeting cytotoxic T-lymphocyte antigen-4, and nivolumab, targeting programmed cell death-1, have been associated with numerous immune-related adverse events. To the authors’ knowledge, this is the first report of aseptic sinusitis as a consequence of immune checkpoint inhibition therapy.

Original languageEnglish (US)
JournalJournal of Immunotherapy
DOIs
StateAccepted/In press - Jun 13 2017

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Sinusitis
CTLA-4 Antigen
Melanoma
Cell Death
Monoclonal Antibodies
Therapeutics
ipilimumab
nivolumab

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

Cite this

Two Cases of Sinusitis Induced by Immune Checkpoint Inhibition. / Dein, Eric; Sharfman, William; Kim, Jean; Gellad, Fouad; Shah, Ami A.; Bingham, Clifton O.; Cappelli, Laura C.

In: Journal of Immunotherapy, 13.06.2017.

Research output: Contribution to journalArticle

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