Two brain cholecystokinin receptors: implications for behavioral actions

Timothy H. Moran, Paul H. Robinson, Michael S. Goldrich, Paul R. McHugh

Research output: Contribution to journalArticle

Abstract

The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalBrain research
Volume362
Issue number1
DOIs
StatePublished - Jan 1 1986

Keywords

  • area postrema
  • autoradiography
  • cholecystokinin
  • nucleus tractus solitarius
  • receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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