Two brain cholecystokinin receptors: implications for behavioral actions

Timothy H. Moran, Paul H. Robinson, Michael S. Goldrich, Paul R. McHugh

Research output: Contribution to journalArticlepeer-review


The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalBrain research
Issue number1
StatePublished - Jan 1 1986


  • area postrema
  • autoradiography
  • cholecystokinin
  • nucleus tractus solitarius
  • receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


Dive into the research topics of 'Two brain cholecystokinin receptors: implications for behavioral actions'. Together they form a unique fingerprint.

Cite this