Two brain cholecystokinin receptors: implications for behavioral actions

Timothy H. Moran; Paul H. Robinson; Michael S. Goldrich; Paul R. McHugh

doi:10.1016/0006-8993(86)91413-7

Two brain cholecystokinin receptors: implications for behavioral actions

Timothy H. Moran, Paul H. Robinson, Michael S. Goldrich, Paul R. McHugh

School of Medicine

Research output: Contribution to journal › Article › peer-review

655 Scopus citations

Abstract

The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [¹²⁵I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Brain research
Volume	362
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91413-7
State	Published - Jan 1 1986

Keywords

area postrema
autoradiography
cholecystokinin
nucleus tractus solitarius
receptor

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)91413-7

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title = "Two brain cholecystokinin receptors: implications for behavioral actions",

abstract = "The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.",

keywords = "area postrema, autoradiography, cholecystokinin, nucleus tractus solitarius, receptor",

author = "Moran, {Timothy H.} and Robinson, {Paul H.} and Goldrich, {Michael S.} and McHugh, {Paul R.}",

note = "Funding Information: This work was supported by NIH Grant AM19302 and by the Wellcome Trust, London, U.K.",

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doi = "10.1016/0006-8993(86)91413-7",

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T1 - Two brain cholecystokinin receptors

T2 - implications for behavioral actions

AU - Moran, Timothy H.

AU - Robinson, Paul H.

AU - Goldrich, Michael S.

AU - McHugh, Paul R.

N1 - Funding Information: This work was supported by NIH Grant AM19302 and by the Wellcome Trust, London, U.K.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.

AB - The distribution and relative specificity of cholecystokinin (CCK) receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33. We identified two distinct binding patterns, suggesting two CCK receptor types. The first is widespread and relatively non-specific. The second, localized to a few subcortical nuclei, has the specificity demonstrated for pancreatic CCK receptors. Localization of this receptor type to the area postrema provides a possible entry site into brain for circulating CCK that (1) would distinguish between CCK and gastrin and (2) could mediate some of CCK's behavioral effects.

KW - area postrema

KW - autoradiography

KW - cholecystokinin

KW - nucleus tractus solitarius

KW - receptor

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Two brain cholecystokinin receptors: implications for behavioral actions

Abstract

Keywords

ASJC Scopus subject areas

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