Two alloantigens on human monocytes: A diallelic system?

Martine J. Jager, Frans H J Claas, Joe D'Amaro, Wink M. Baldwin, Jon J. van Rood

Research output: Contribution to journalArticlepeer-review

Abstract

A positive monocyte crossmatch and therefore anti-monocyte antibodies are negative factors in bone marrow and renal transplantation. When the monocyte antigens themselves can be recognized, matching for the antigens involved here may become a possibility. In order to find useful anti-monocyte sera as typing reagents, human sera were screened aganst panel cells. Several monocyte specific sera were obtained. These sera recognized two monocyte antigens, HMA-1 and HMA-2. No similarity with any of the HLA antigens was observed. Every individual tested was positive for at least one of these two monocyte antigens, suggesting that HMA-1 and HMA-2 constitute a diallelic system.

Original languageEnglish (US)
Pages (from-to)215-224
Number of pages10
JournalHuman Immunology
Volume19
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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