TY - JOUR
T1 - Twin Study on Ocular Pressure Following Topically Applied Dexamethasone
T2 - II. Inheritance of Variation in Pressure Response
AU - Schwartz, J. Theodore
AU - Reuling, Frank H.
AU - Feinleib, Manning
AU - Garrison, Robert J.
AU - Collie, Doris J.
PY - 1973
Y1 - 1973
N2 - A twin study was undertaken to reevaluate a widely held monogenic hypothesis relating to the ocular hypertensive steroid response. In the present (part II) analysis, intrapair differences for steroid response among the monozygotic (MZ) and dizygotic (DZ) samples were compared. Responsiveness was treated as both a qualitative and quantitative trait. For the parameter change in pressure, significant differences were never observed between the MZ and DZ samples and heritability index was consistently low. For final pressure, differences between the twin classes showed a mixed pattern of significance; the heritability index was low- to mid-range. Such observations do not support a predominant role of inheritance. It seems evident that a theory of simple monogenic determination can be questioned on the basis of these new findings.
AB - A twin study was undertaken to reevaluate a widely held monogenic hypothesis relating to the ocular hypertensive steroid response. In the present (part II) analysis, intrapair differences for steroid response among the monozygotic (MZ) and dizygotic (DZ) samples were compared. Responsiveness was treated as both a qualitative and quantitative trait. For the parameter change in pressure, significant differences were never observed between the MZ and DZ samples and heritability index was consistently low. For final pressure, differences between the twin classes showed a mixed pattern of significance; the heritability index was low- to mid-range. Such observations do not support a predominant role of inheritance. It seems evident that a theory of simple monogenic determination can be questioned on the basis of these new findings.
UR - http://www.scopus.com/inward/record.url?scp=0015905841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015905841&partnerID=8YFLogxK
U2 - 10.1001/archopht.1973.01000050283006
DO - 10.1001/archopht.1973.01000050283006
M3 - Article
C2 - 4795755
AN - SCOPUS:0015905841
SN - 0003-9950
VL - 90
SP - 281
EP - 286
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 4
ER -