Twenty years of syngap research: From synapses to cognition

Timothy R. Gamache, Yoichi Araki, Richard L. Huganir

Research output: Contribution to journalReview article

Abstract

SynGAP is a potent regulator of biochemical signaling in neurons and plays critical roles in neuronal function. It was first identified in 1998, and has since been extensively characterized as a mediator of synaptic plasticity. Because of its involvement in synaptic plasticity, SynGAP has emerged as a critical protein for normal cognitive function. In recent years, mutations in the SYNGAP1gene have been shown to cause intellectual disability in humans and have been linked to other neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia. While the structure and biochemical function of SynGAP have been well characterized, a unified understanding of the various roles of SynGAP at the synapse and its contributions to neuronal function remains to be achieved. In this review, we summarize and discuss the current understanding of the multifactorial role of SynGAP in regulating neuronal function gathered over the last two decades.

Original languageEnglish (US)
Pages (from-to)1596-1605
Number of pages10
JournalJournal of Neuroscience
Volume40
Issue number8
DOIs
StatePublished - Feb 19 2020

ASJC Scopus subject areas

  • Neuroscience(all)

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