TY - JOUR
T1 - Twenty years of syngap research
T2 - From synapses to cognition
AU - Gamache, Timothy R.
AU - Araki, Yoichi
AU - Huganir, Richard L.
N1 - Publisher Copyright:
© 2020 the authors
PY - 2020/2/19
Y1 - 2020/2/19
N2 - SynGAP is a potent regulator of biochemical signaling in neurons and plays critical roles in neuronal function. It was first identified in 1998, and has since been extensively characterized as a mediator of synaptic plasticity. Because of its involvement in synaptic plasticity, SynGAP has emerged as a critical protein for normal cognitive function. In recent years, mutations in the SYNGAP1gene have been shown to cause intellectual disability in humans and have been linked to other neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia. While the structure and biochemical function of SynGAP have been well characterized, a unified understanding of the various roles of SynGAP at the synapse and its contributions to neuronal function remains to be achieved. In this review, we summarize and discuss the current understanding of the multifactorial role of SynGAP in regulating neuronal function gathered over the last two decades.
AB - SynGAP is a potent regulator of biochemical signaling in neurons and plays critical roles in neuronal function. It was first identified in 1998, and has since been extensively characterized as a mediator of synaptic plasticity. Because of its involvement in synaptic plasticity, SynGAP has emerged as a critical protein for normal cognitive function. In recent years, mutations in the SYNGAP1gene have been shown to cause intellectual disability in humans and have been linked to other neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia. While the structure and biochemical function of SynGAP have been well characterized, a unified understanding of the various roles of SynGAP at the synapse and its contributions to neuronal function remains to be achieved. In this review, we summarize and discuss the current understanding of the multifactorial role of SynGAP in regulating neuronal function gathered over the last two decades.
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U2 - 10.1523/JNEUROSCI.0420-19.2020
DO - 10.1523/JNEUROSCI.0420-19.2020
M3 - Review article
C2 - 32075947
AN - SCOPUS:85079742619
SN - 0270-6474
VL - 40
SP - 1596
EP - 1605
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 8
ER -