Turnover and synthesis of biogenic amines in discrete brainstem nuclei of the rabbit

M. Colleen McNamara, Edward Lawson

Research output: Contribution to journalArticle

Abstract

By use of a microtechnique and sensitive enzymatic isotopic assays norepinephrine (NE), dopamine (DA) and serotonin (5-HT) turnover rates were measured in 6 discrete brainstem regions. The results from young (3 days) and adult (1 year) rabbits were compared. In the dorsal raphe nucleus (dr) of the younger animals the slopes of disappearance of NE and 5-HT were significantly higher than in the adults. Whereas, in the dr the slope of the decline of DA was found to be significantly lower in younger animals. In the dr turnover rates of NE and 5-HT were higher in the young animals. However, higher turnover rates for DA were seen only in the LC-A6 region. The young animals had significantly lower turnover times for NE and 5-HT in the dr. The nts was the only nuclear group to reach significance for DA, and the young animals had longer turnover times when compared to adults. These results are indicative of the different roles the neurotransmitter systems play in maintaining homeostasis. The delicate balances in these systems in the brains of younger animals may contribute to their increased susceptibility to perturbations.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalBrain Research
Volume299
Issue number2
DOIs
StatePublished - May 14 1984
Externally publishedYes

Fingerprint

Biogenic Amines
Brain Stem
Serotonin
Rabbits
Dopamine
Norepinephrine
Enzyme Assays
Neurotransmitter Agents
Homeostasis
Dorsal Raphe Nucleus
Brain

Keywords

  • amines
  • brainstem
  • development
  • rabbit
  • respiration
  • turnover

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Turnover and synthesis of biogenic amines in discrete brainstem nuclei of the rabbit. / McNamara, M. Colleen; Lawson, Edward.

In: Brain Research, Vol. 299, No. 2, 14.05.1984, p. 259-264.

Research output: Contribution to journalArticle

@article{e5a2ddd91cb44ba8bfe612084e7df233,
title = "Turnover and synthesis of biogenic amines in discrete brainstem nuclei of the rabbit",
abstract = "By use of a microtechnique and sensitive enzymatic isotopic assays norepinephrine (NE), dopamine (DA) and serotonin (5-HT) turnover rates were measured in 6 discrete brainstem regions. The results from young (3 days) and adult (1 year) rabbits were compared. In the dorsal raphe nucleus (dr) of the younger animals the slopes of disappearance of NE and 5-HT were significantly higher than in the adults. Whereas, in the dr the slope of the decline of DA was found to be significantly lower in younger animals. In the dr turnover rates of NE and 5-HT were higher in the young animals. However, higher turnover rates for DA were seen only in the LC-A6 region. The young animals had significantly lower turnover times for NE and 5-HT in the dr. The nts was the only nuclear group to reach significance for DA, and the young animals had longer turnover times when compared to adults. These results are indicative of the different roles the neurotransmitter systems play in maintaining homeostasis. The delicate balances in these systems in the brains of younger animals may contribute to their increased susceptibility to perturbations.",
keywords = "amines, brainstem, development, rabbit, respiration, turnover",
author = "McNamara, {M. Colleen} and Edward Lawson",
year = "1984",
month = "5",
day = "14",
doi = "10.1016/0006-8993(84)90707-8",
language = "English (US)",
volume = "299",
pages = "259--264",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Turnover and synthesis of biogenic amines in discrete brainstem nuclei of the rabbit

AU - McNamara, M. Colleen

AU - Lawson, Edward

PY - 1984/5/14

Y1 - 1984/5/14

N2 - By use of a microtechnique and sensitive enzymatic isotopic assays norepinephrine (NE), dopamine (DA) and serotonin (5-HT) turnover rates were measured in 6 discrete brainstem regions. The results from young (3 days) and adult (1 year) rabbits were compared. In the dorsal raphe nucleus (dr) of the younger animals the slopes of disappearance of NE and 5-HT were significantly higher than in the adults. Whereas, in the dr the slope of the decline of DA was found to be significantly lower in younger animals. In the dr turnover rates of NE and 5-HT were higher in the young animals. However, higher turnover rates for DA were seen only in the LC-A6 region. The young animals had significantly lower turnover times for NE and 5-HT in the dr. The nts was the only nuclear group to reach significance for DA, and the young animals had longer turnover times when compared to adults. These results are indicative of the different roles the neurotransmitter systems play in maintaining homeostasis. The delicate balances in these systems in the brains of younger animals may contribute to their increased susceptibility to perturbations.

AB - By use of a microtechnique and sensitive enzymatic isotopic assays norepinephrine (NE), dopamine (DA) and serotonin (5-HT) turnover rates were measured in 6 discrete brainstem regions. The results from young (3 days) and adult (1 year) rabbits were compared. In the dorsal raphe nucleus (dr) of the younger animals the slopes of disappearance of NE and 5-HT were significantly higher than in the adults. Whereas, in the dr the slope of the decline of DA was found to be significantly lower in younger animals. In the dr turnover rates of NE and 5-HT were higher in the young animals. However, higher turnover rates for DA were seen only in the LC-A6 region. The young animals had significantly lower turnover times for NE and 5-HT in the dr. The nts was the only nuclear group to reach significance for DA, and the young animals had longer turnover times when compared to adults. These results are indicative of the different roles the neurotransmitter systems play in maintaining homeostasis. The delicate balances in these systems in the brains of younger animals may contribute to their increased susceptibility to perturbations.

KW - amines

KW - brainstem

KW - development

KW - rabbit

KW - respiration

KW - turnover

UR - http://www.scopus.com/inward/record.url?scp=0021253261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021253261&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(84)90707-8

DO - 10.1016/0006-8993(84)90707-8

M3 - Article

C2 - 6733449

AN - SCOPUS:0021253261

VL - 299

SP - 259

EP - 264

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -