TY - JOUR
T1 - Turning cancer's metabolic plasticity into fragility- an evolving paradigm
AU - Ganapathy-Kanniappan, Shanmugasundaram
N1 - Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.
PY - 2018/9/2
Y1 - 2018/9/2
N2 - In an elegant report, Corbet et al1 recently demonstrated the much needed insight to exploit cancer's metabolic reprogramming for potential therapeutic intervention. In brief, the findings underscore the principle that abrogation of mitochondrial pyruvate metabolism upregulates glycolysis, and sensitizes cancer cells to radiation. Distinctive from the conventional approach of inhibition/ down-regulation of glycolysis, this emerging paradigm of forced-upregulation of glycolysis (i.e., a “hyperglycolytic” phenotype) concomitant with a reduced mitochondrial capacity turns the metabolic plasticity into vulnerability that may have implications in therapeutic targeting. Nevertheless, this commendable report1 also provokes scientific curiosity and future directions of research on the opportunities and challenges of such forced upregulation of glycolysis in cancer.
AB - In an elegant report, Corbet et al1 recently demonstrated the much needed insight to exploit cancer's metabolic reprogramming for potential therapeutic intervention. In brief, the findings underscore the principle that abrogation of mitochondrial pyruvate metabolism upregulates glycolysis, and sensitizes cancer cells to radiation. Distinctive from the conventional approach of inhibition/ down-regulation of glycolysis, this emerging paradigm of forced-upregulation of glycolysis (i.e., a “hyperglycolytic” phenotype) concomitant with a reduced mitochondrial capacity turns the metabolic plasticity into vulnerability that may have implications in therapeutic targeting. Nevertheless, this commendable report1 also provokes scientific curiosity and future directions of research on the opportunities and challenges of such forced upregulation of glycolysis in cancer.
KW - aerobic glycolysis
KW - metabolic plasticity
KW - mitochondrial OxPhos
KW - mitochondrial pyruvate carrier
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U2 - 10.1080/15384047.2018.1471441
DO - 10.1080/15384047.2018.1471441
M3 - Article
C2 - 29723104
AN - SCOPUS:85047431522
SN - 1538-4047
VL - 19
SP - 763
EP - 765
JO - Cancer Biology and Therapy
JF - Cancer Biology and Therapy
IS - 9
ER -