Tuning in to the voices: A multisite fMRI study of auditory hallucinations

Judith M. Ford, Brian J. Roach, Kasper W. Jorgensen, Jessica A. Turner, Gregory G. Brown, Randy Notestine, Amanda Bischoff-Grethe, Douglas Greve, Cynthia Wible, John Lauriello, Aysenil Belger, Bryon A. Mueller, Vince Daniel Calhoun, Adrian Preda, David Keator, Daniel S. O'Leary, Kelvin O. Lim, Gary Glover, Steven G. Potkin, Daniel H. Mathalon

Research output: Contribution to journalArticle

Abstract

Introduction: Auditory hallucinations or voices are experienced by 75% of people diagnosed with schizophrenia. We presumed that auditory cortex of schizophrenia patients who experience hallucinations is tonically "tuned" to internal auditory channels, at the cost of processing external sounds, both speech and nonspeech. Accordingly, we predicted that patients who hallucinate would show less auditory cortical activation to external acoustic stimuli than patients who did not. Methods: At 9 Functional Imaging Biomedical Informatics Research Network (FBIRN) sites, whole-brain images from 106 patients and 111 healthy comparison subjects were collected while subjects performed an auditory target detection task. Data were processed with the FBIRN processing stream. A region of interest analysis extracted activation values from primary (BA41) and secondary auditory cortex (BA42), auditory association cortex (BA22), and middle temporal gyrus (BA21). Patients were sorted into hallucinators (n = 66) and nonhallucinators (n = 40) based on symptom ratings done during the previous week. Results: Hallucinators had less activation to probe tones in left primary auditory cortex (BA41) than nonhallucinators. This effect was not seen on the right. Discussion: Although "voices" are the anticipated sensory experience, it appears that even primary auditory cortex is "turned on" and "tuned in" to process internal acoustic information at the cost of processing external sounds. Although this study was not designed to probe cortical competition for auditory resources, we were able to take advantage of the data and find significant effects, perhaps because of the power afforded by such a large sample.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalSchizophrenia Bulletin
Volume35
Issue number1
DOIs
StatePublished - Jan 2009
Externally publishedYes

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Auditory Cortex
Hallucinations
Magnetic Resonance Imaging
Informatics
Acoustics
Biomedical Research
Schizophrenia
Activation Analysis
Phonetics
Temporal Lobe
Healthy Volunteers
Brain

Keywords

  • Auditory cortex
  • Auditory hallucinations
  • fMRI
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Ford, J. M., Roach, B. J., Jorgensen, K. W., Turner, J. A., Brown, G. G., Notestine, R., ... Mathalon, D. H. (2009). Tuning in to the voices: A multisite fMRI study of auditory hallucinations. Schizophrenia Bulletin, 35(1), 58-66. https://doi.org/10.1093/schbul/sbn140

Tuning in to the voices : A multisite fMRI study of auditory hallucinations. / Ford, Judith M.; Roach, Brian J.; Jorgensen, Kasper W.; Turner, Jessica A.; Brown, Gregory G.; Notestine, Randy; Bischoff-Grethe, Amanda; Greve, Douglas; Wible, Cynthia; Lauriello, John; Belger, Aysenil; Mueller, Bryon A.; Calhoun, Vince Daniel; Preda, Adrian; Keator, David; O'Leary, Daniel S.; Lim, Kelvin O.; Glover, Gary; Potkin, Steven G.; Mathalon, Daniel H.

In: Schizophrenia Bulletin, Vol. 35, No. 1, 01.2009, p. 58-66.

Research output: Contribution to journalArticle

Ford, JM, Roach, BJ, Jorgensen, KW, Turner, JA, Brown, GG, Notestine, R, Bischoff-Grethe, A, Greve, D, Wible, C, Lauriello, J, Belger, A, Mueller, BA, Calhoun, VD, Preda, A, Keator, D, O'Leary, DS, Lim, KO, Glover, G, Potkin, SG & Mathalon, DH 2009, 'Tuning in to the voices: A multisite fMRI study of auditory hallucinations', Schizophrenia Bulletin, vol. 35, no. 1, pp. 58-66. https://doi.org/10.1093/schbul/sbn140
Ford JM, Roach BJ, Jorgensen KW, Turner JA, Brown GG, Notestine R et al. Tuning in to the voices: A multisite fMRI study of auditory hallucinations. Schizophrenia Bulletin. 2009 Jan;35(1):58-66. https://doi.org/10.1093/schbul/sbn140
Ford, Judith M. ; Roach, Brian J. ; Jorgensen, Kasper W. ; Turner, Jessica A. ; Brown, Gregory G. ; Notestine, Randy ; Bischoff-Grethe, Amanda ; Greve, Douglas ; Wible, Cynthia ; Lauriello, John ; Belger, Aysenil ; Mueller, Bryon A. ; Calhoun, Vince Daniel ; Preda, Adrian ; Keator, David ; O'Leary, Daniel S. ; Lim, Kelvin O. ; Glover, Gary ; Potkin, Steven G. ; Mathalon, Daniel H. / Tuning in to the voices : A multisite fMRI study of auditory hallucinations. In: Schizophrenia Bulletin. 2009 ; Vol. 35, No. 1. pp. 58-66.
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AU - Calhoun, Vince Daniel

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AU - Keator, David

AU - O'Leary, Daniel S.

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N2 - Introduction: Auditory hallucinations or voices are experienced by 75% of people diagnosed with schizophrenia. We presumed that auditory cortex of schizophrenia patients who experience hallucinations is tonically "tuned" to internal auditory channels, at the cost of processing external sounds, both speech and nonspeech. Accordingly, we predicted that patients who hallucinate would show less auditory cortical activation to external acoustic stimuli than patients who did not. Methods: At 9 Functional Imaging Biomedical Informatics Research Network (FBIRN) sites, whole-brain images from 106 patients and 111 healthy comparison subjects were collected while subjects performed an auditory target detection task. Data were processed with the FBIRN processing stream. A region of interest analysis extracted activation values from primary (BA41) and secondary auditory cortex (BA42), auditory association cortex (BA22), and middle temporal gyrus (BA21). Patients were sorted into hallucinators (n = 66) and nonhallucinators (n = 40) based on symptom ratings done during the previous week. Results: Hallucinators had less activation to probe tones in left primary auditory cortex (BA41) than nonhallucinators. This effect was not seen on the right. Discussion: Although "voices" are the anticipated sensory experience, it appears that even primary auditory cortex is "turned on" and "tuned in" to process internal acoustic information at the cost of processing external sounds. Although this study was not designed to probe cortical competition for auditory resources, we were able to take advantage of the data and find significant effects, perhaps because of the power afforded by such a large sample.

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