Tunable oxygen-releasing, 3d-printed scaffolds improve in vivo osteogenesis

Ashley L. Farris, Dennis Lambrechts, Nicholas Zhang, Alexandra Rindone, Ethan L. Nyberg, Aine O’sullivan, S. J. Burris, Kendall Free, Warren L. Grayson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: The clinical success of tissue engineering approaches is currently limited to acellular, thin, or small scaffolds. One reason for this is the limited O2 supply when cells are implanted, which can result in the formation of necrotic regions due to anoxia in large 3D scaffolds. Our group previously demonstrated a facile method to deliver O2 to cells using scaffolds containing polymeric microparticles, called μtanks, that are hyperbarically loaded with O2. In this study, we demonstrate the ability to fabricate biodegradable μtanks, 3D-print μtank scaffolds with tunable O2 release, and demonstrate that these materials enhance osteogenesis.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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