TY - GEN
T1 - Tunable oxygen-releasing, 3d-printed scaffolds improve in vivo osteogenesis
AU - Farris, Ashley L.
AU - Lambrechts, Dennis
AU - Zhang, Nicholas
AU - Rindone, Alexandra
AU - Nyberg, Ethan L.
AU - O’sullivan, Aine
AU - Burris, S. J.
AU - Free, Kendall
AU - Grayson, Warren L.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: The clinical success of tissue engineering approaches is currently limited to acellular, thin, or small scaffolds. One reason for this is the limited O2 supply when cells are implanted, which can result in the formation of necrotic regions due to anoxia in large 3D scaffolds. Our group previously demonstrated a facile method to deliver O2 to cells using scaffolds containing polymeric microparticles, called μtanks, that are hyperbarically loaded with O2. In this study, we demonstrate the ability to fabricate biodegradable μtanks, 3D-print μtank scaffolds with tunable O2 release, and demonstrate that these materials enhance osteogenesis.
AB - Statement of Purpose: The clinical success of tissue engineering approaches is currently limited to acellular, thin, or small scaffolds. One reason for this is the limited O2 supply when cells are implanted, which can result in the formation of necrotic regions due to anoxia in large 3D scaffolds. Our group previously demonstrated a facile method to deliver O2 to cells using scaffolds containing polymeric microparticles, called μtanks, that are hyperbarically loaded with O2. In this study, we demonstrate the ability to fabricate biodegradable μtanks, 3D-print μtank scaffolds with tunable O2 release, and demonstrate that these materials enhance osteogenesis.
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M3 - Conference contribution
AN - SCOPUS:85065434674
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 425
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -