Tumour mutational burden as a biomarker for immunotherapy: Current data and emerging concepts

Jean David Fumet, Caroline Truntzer, Mark Yarchoan, Francois Ghiringhelli

Research output: Contribution to journalReview articlepeer-review

Abstract

Treatment with immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or its ligand (PD-L1) can generate durable responses in various cancer types, but only in a subset of patients. The use of predictive biomarkers for response to PD-1/PD-L1 inhibitors is critical for patient selection. Expression of PD-L1 has demonstrated utility in patient selection. Tumour mutational burden (TMB) is an emerging biomarker for response to PD-1/PD-L1 inhibitors. The evaluation of this biomarker is based on the hypothesis that a high number of mutations in somatic exonic regions will lead to an increase in neoantigen production, which could then be recognised by CD8+ T cells, resulting in improved immune responses. In this review, we will discuss rationale and implementation of TMB usage in patients, development of different methods to assess it, current limitations and technical issues to use this biomarker as a diagnostic test and propose future perspectives beyond TMB.

Original languageEnglish (US)
Pages (from-to)40-50
Number of pages11
JournalEuropean Journal of Cancer
Volume131
DOIs
StatePublished - May 2020

Keywords

  • Biomarker
  • Immunotherapy
  • Tumour mutational burden

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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