Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas

A. Handra-Luca, S. M. Hong, K. Walter, C. Wolfgang, R. Hruban, M. Goggins

Research output: Contribution to journalArticle

Abstract

Purpose: Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas. Methods: Vimentin expression was detected by immunohistochemistry on tissue microarrays of surgically resected pancreatic ductal adenocarcinomas from 387 patients. The percentage of vimentin-immunolabelled neoplastic cells was correlated with outcome and with clinico-pathological factors using the Kaplan-Meier method and Cox multivariate survival models. Results: In all, 45% of primary pancreatic adenocarcinomas contained neoplastic cells that expressed vimentin, and in 27.5% of the cancers >10% of cells expressed vimentin. Vimentin expression was correlated with poor histological differentiation. By both uni- and multivariate survival analysis, neoplastic vimentin expression (P<0.01, HR 1.52, 95% confidence interval 1.14-2.04) was an indicator of a shorter postsurgical survival independent of other clinico-pathological variables. Conclusion: The presence of vimentin-expressing tumour epithelial cells in surgically resected pancreatic adenocarcinomas independently predicted a shorter postsurgical survival.

Original languageEnglish (US)
Pages (from-to)1296-1302
Number of pages7
JournalBritish journal of cancer
Volume104
Issue number8
DOIs
StatePublished - Apr 12 2011

Keywords

  • adenocarcinoma
  • pancreas
  • prognosis
  • vimentin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas'. Together they form a unique fingerprint.

  • Cite this