Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas

A. Handra-Luca, S. M. Hong, K. Walter, Christopher Wolfgang, Ralph H Hruban, Michael S Goggins

Research output: Contribution to journalArticle

Abstract

Purpose: Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas. Methods: Vimentin expression was detected by immunohistochemistry on tissue microarrays of surgically resected pancreatic ductal adenocarcinomas from 387 patients. The percentage of vimentin-immunolabelled neoplastic cells was correlated with outcome and with clinico-pathological factors using the Kaplan-Meier method and Cox multivariate survival models. Results: In all, 45% of primary pancreatic adenocarcinomas contained neoplastic cells that expressed vimentin, and in 27.5% of the cancers >10% of cells expressed vimentin. Vimentin expression was correlated with poor histological differentiation. By both uni- and multivariate survival analysis, neoplastic vimentin expression (P

Original languageEnglish (US)
Pages (from-to)1296-1302
Number of pages7
JournalBritish Journal of Cancer
Volume104
Issue number8
DOIs
StatePublished - Apr 12 2011

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Vimentin
Adenocarcinoma
Neoplasms
Differentiation Antigens
Survival Analysis
Multivariate Analysis
Immunohistochemistry
Carcinoma
Survival

Keywords

  • adenocarcinoma
  • pancreas
  • prognosis
  • vimentin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas. / Handra-Luca, A.; Hong, S. M.; Walter, K.; Wolfgang, Christopher; Hruban, Ralph H; Goggins, Michael S.

In: British Journal of Cancer, Vol. 104, No. 8, 12.04.2011, p. 1296-1302.

Research output: Contribution to journalArticle

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AU - Goggins, Michael S

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N2 - Purpose: Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas. Methods: Vimentin expression was detected by immunohistochemistry on tissue microarrays of surgically resected pancreatic ductal adenocarcinomas from 387 patients. The percentage of vimentin-immunolabelled neoplastic cells was correlated with outcome and with clinico-pathological factors using the Kaplan-Meier method and Cox multivariate survival models. Results: In all, 45% of primary pancreatic adenocarcinomas contained neoplastic cells that expressed vimentin, and in 27.5% of the cancers >10% of cells expressed vimentin. Vimentin expression was correlated with poor histological differentiation. By both uni- and multivariate survival analysis, neoplastic vimentin expression (P

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