Tumors of the skin in the HRA Skh mouse after treatment with 8-methoxypsoralen and UVA radiation

June K. Dunnick, P. Donald Forbes, Scot L. Eustis, Jerry F. Hardisty, Dawn G. Goodman

Research output: Contribution to journalArticle

Abstract

8-Methoxypsoralen (8-MOP) with and without UVA radiation was administered to HRA Skh mice (36 animals per treatment group) three times a week in the feed for a total dose of 9-80 mg/kg/week for 52 weeks. Most of the animals at the top dose of 8-MOP with UVA radiation had developed skin toxicity and/or skin tumors by 52 weeks. The skin lesions seen after treatment with 8-MOP and UVA radiation were characterized as squamous cell hyperplasia, squamous cell papilloma, and squamous cell carcinoma and are similar to what has been reported in humans after exposure to 8-MOP and UVA. Squamous cell hyperplasia and acute inflammation of the cornea were also seen in some of the treated female mice. Oral administration of 8-MOP and UVA did not result in a carcinogenic response to other organ systems. There were no increases in skin neoplasms after 8-MOP or UVA radiation alone. 8-MOP given in combination with UVA was carcinogenic to the skin of mice at dose levels similar to those used to treat psoriasis in humans.

Original languageEnglish (US)
Pages (from-to)92-102
Number of pages11
JournalFundamental and Applied Toxicology
Volume16
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Methoxsalen
Tumors
Skin
Radiation
Neoplasms
Therapeutics
Hyperplasia
Animals
Epithelial Cells
Papilloma
Skin Neoplasms
Psoriasis
Cornea
Dosimetry
Oral Administration
Toxicity
Squamous Cell Carcinoma
Inflammation

ASJC Scopus subject areas

  • Toxicology

Cite this

Tumors of the skin in the HRA Skh mouse after treatment with 8-methoxypsoralen and UVA radiation. / Dunnick, June K.; Forbes, P. Donald; Eustis, Scot L.; Hardisty, Jerry F.; Goodman, Dawn G.

In: Fundamental and Applied Toxicology, Vol. 16, No. 1, 1991, p. 92-102.

Research output: Contribution to journalArticle

Dunnick, June K. ; Forbes, P. Donald ; Eustis, Scot L. ; Hardisty, Jerry F. ; Goodman, Dawn G. / Tumors of the skin in the HRA Skh mouse after treatment with 8-methoxypsoralen and UVA radiation. In: Fundamental and Applied Toxicology. 1991 ; Vol. 16, No. 1. pp. 92-102.
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