Tumors line up for a letdown

Joshua T. Mendell

doi:10.1038/ng0709-768

Tumors line up for a letdown

Joshua T. Mendell

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.

Original language	English (US)
Pages (from-to)	768-769
Number of pages	2
Journal	Nature genetics
Volume	41
Issue number	7
DOIs	https://doi.org/10.1038/ng0709-768
State	Published - Jul 2009
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1038/ng0709-768

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title = "Tumors line up for a letdown",

abstract = "MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.",

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AB - MicroRNAs (miRNAs) and the pathways that regulate their expression have critical functions during normal development. A new study demonstrates that select cancer cells have appropriated one developmental mechanism of miRNA regulation, the inhibition of let-7 biogenesis by the Lin-28 and Lin-28B RNA binding proteins, to rid themselves of an antitumorigenic miRNA.

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JO - Nature genetics

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Tumors line up for a letdown

Abstract

ASJC Scopus subject areas

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