Tumor suppression by chromosome 11 is not due to cellular senescence

Yi Ning; Jerry W. Shay; Mercedes Lovell; Linda Taylor; David H. Ledbetter; Olivia M. Pereira-Smith

doi:10.1016/0014-4827(91)90179-X

Tumor suppression by chromosome 11 is not due to cellular senescence

Yi Ning, Jerry W. Shay, Mercedes Lovell, Linda Taylor, David H. Ledbetter, Olivia M. Pereira-Smith

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Previous hybrid studies involving fusion of normal with immortal human cells indicated that the phenotype of cellular senescence is dominant and that immortality results from recessive changes in normal growth regulatory genes. We have further assigned 28 different immortal human cell lines to at least four complementation groups for indefinite division. In order to identify the chromosomes involved in regulating cell proliferation, we have introduced single human chromosomes by microcell fusion into immortal human cells representative of the different complementation groups. Our results demonstrate that the introduction of chromosome 11, implicated in tumor suppression, does not cause cellular senescence in three different immortal human cell lines tested.

Original language	English (US)
Pages (from-to)	220-226
Number of pages	7
Journal	Experimental cell research
Volume	192
Issue number	1
DOIs	https://doi.org/10.1016/0014-4827(91)90179-X
State	Published - Jan 1991

ASJC Scopus subject areas

Cell Biology

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title = "Tumor suppression by chromosome 11 is not due to cellular senescence",

abstract = "Previous hybrid studies involving fusion of normal with immortal human cells indicated that the phenotype of cellular senescence is dominant and that immortality results from recessive changes in normal growth regulatory genes. We have further assigned 28 different immortal human cell lines to at least four complementation groups for indefinite division. In order to identify the chromosomes involved in regulating cell proliferation, we have introduced single human chromosomes by microcell fusion into immortal human cells representative of the different complementation groups. Our results demonstrate that the introduction of chromosome 11, implicated in tumor suppression, does not cause cellular senescence in three different immortal human cell lines tested.",

author = "Yi Ning and Shay, {Jerry W.} and Mercedes Lovell and Linda Taylor and Ledbetter, {David H.} and Pereira-Smith, {Olivia M.}",

note = "Funding Information: We are grateful to Dr. Ann Killary for her assistance in setting up the microcell fusion technique in our laboratory. This work was supported by National Institutes of Health Grants AG05333, POlAG07123, AG07992, and CA 50195, the Pilgeram Fund for Aging Research, American Cancer Society Grant CD-347A. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1991",

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doi = "10.1016/0014-4827(91)90179-X",

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AU - Ning, Yi

AU - Shay, Jerry W.

AU - Lovell, Mercedes

AU - Taylor, Linda

AU - Ledbetter, David H.

AU - Pereira-Smith, Olivia M.

N1 - Funding Information: We are grateful to Dr. Ann Killary for her assistance in setting up the microcell fusion technique in our laboratory. This work was supported by National Institutes of Health Grants AG05333, POlAG07123, AG07992, and CA 50195, the Pilgeram Fund for Aging Research, American Cancer Society Grant CD-347A. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1991/1

Y1 - 1991/1

N2 - Previous hybrid studies involving fusion of normal with immortal human cells indicated that the phenotype of cellular senescence is dominant and that immortality results from recessive changes in normal growth regulatory genes. We have further assigned 28 different immortal human cell lines to at least four complementation groups for indefinite division. In order to identify the chromosomes involved in regulating cell proliferation, we have introduced single human chromosomes by microcell fusion into immortal human cells representative of the different complementation groups. Our results demonstrate that the introduction of chromosome 11, implicated in tumor suppression, does not cause cellular senescence in three different immortal human cell lines tested.

AB - Previous hybrid studies involving fusion of normal with immortal human cells indicated that the phenotype of cellular senescence is dominant and that immortality results from recessive changes in normal growth regulatory genes. We have further assigned 28 different immortal human cell lines to at least four complementation groups for indefinite division. In order to identify the chromosomes involved in regulating cell proliferation, we have introduced single human chromosomes by microcell fusion into immortal human cells representative of the different complementation groups. Our results demonstrate that the introduction of chromosome 11, implicated in tumor suppression, does not cause cellular senescence in three different immortal human cell lines tested.

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Tumor suppression by chromosome 11 is not due to cellular senescence

Abstract

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