Tumor-specific changes in mtDNA content in human cancer

Elizabeth Mambo, Aditi Chatterjee, Mingzhao Xing, Giovanni Tallini, Bryan R. Haugen, Sai Ching J. Yeung, Saraswati Sukumar, David Sidransky

Research output: Contribution to journalArticlepeer-review

Abstract

Mitochondrial DNA (mtDNA) alterations are associated with various cancer types, suggesting that the mitochondrial genome may be a critical contributing factor in carcinogenesis. mtDNA alterations have been suggested as a potentially sensitive and specific biomarker for several cancer types. We examined mtDNA content in 25 pairs of normal and tumor breast tissue samples, 37 papillary thyroid carcinoma (PTC), 21 benign thyroid neoplasms and in 20 paired normal and PTC samples. Our results showed that mtDNA content was reduced in 80% of the breast tumors relative to their corresponding normal. mtDNA was increased in papillary thyroid carcinomas, however, when compared to the corresponding normal DNA taken from the same individual. Also, mtDNA content was increased in none-paired PTC samples compared to the normal controls. Our findings indicate that changes in mtDNA content during carcinogenesis may be regulated in a tumor specific manner. Additionally, changes in mtDNA levels did not correlate with tumor grade and metastasis, suggesting that these alterations may occur in the early stages of tumorigenesis. Our findings suggest that mtDNA content can be used as a molecular diagnostic tool to help identify genetic abnormalities in human tumors.

Original languageEnglish (US)
Pages (from-to)920-924
Number of pages5
JournalInternational Journal of Cancer
Volume116
Issue number6
DOIs
StatePublished - Oct 10 2005

Keywords

  • Breast cancer
  • Thyroid cancer
  • mtDNA content

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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