Tumor size increase following preoperative radiation of soft tissue sarcomas does not affect prognosis

Gadini O. Delisca, Vignesh K. Alamanda, Kristin R. Archer, Yanna Song, Herbert S. Schwartz, Ginger E. Holt

Research output: Contribution to journalArticle

Abstract

Background and Objectives Administration of preoperative radiotherapy for extremity soft tissue sarcoma improves local control, while allowing for a more conservative surgical resection. During radiation treatment tumor size typically decreases or remains constant. In a subset of patients, however, a size increase in the tumor occurs. Our goal was to investigate the prognosis of patients who had a size increase of at least 20% over the course of preoperative radiotherapy versus those who did not. Methods This retrospective study evaluated 70 patients treated for localized primary STS of the extremities between January 2000 and December 2008. Kaplan-Meier curves for disease-specific and metastasis-free survival were calculated for both groups. Results Sixty-one patients had stable or decrease local tumor size following preoperative radiotherapy and nine patients had an increase of at least 20% in tumor size. There were no statistically significant differences found in disease-specific survival and metastasis-free survival (Gray's test, P = 0.93 and P = 0.68, respectively) among the two groups. Conclusion Our results indicate that a 20% increase in tumor size following preoperative radiotherapy did not result in a worse outcome for patients when compared to those who had stable or decrease local tumor size following preoperative radiotherapy.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalJournal of Surgical Oncology
Volume107
Issue number7
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Sarcoma
Radiation
Radiotherapy
Neoplasms
Survival
Extremities
Neoplasm Metastasis
Retrospective Studies

Keywords

  • metastasis
  • radiation
  • soft tissue sarcoma
  • survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Delisca, G. O., Alamanda, V. K., Archer, K. R., Song, Y., Schwartz, H. S., & Holt, G. E. (2013). Tumor size increase following preoperative radiation of soft tissue sarcomas does not affect prognosis. Journal of Surgical Oncology, 107(7), 723-727. https://doi.org/10.1002/jso.23322

Tumor size increase following preoperative radiation of soft tissue sarcomas does not affect prognosis. / Delisca, Gadini O.; Alamanda, Vignesh K.; Archer, Kristin R.; Song, Yanna; Schwartz, Herbert S.; Holt, Ginger E.

In: Journal of Surgical Oncology, Vol. 107, No. 7, 06.2013, p. 723-727.

Research output: Contribution to journalArticle

Delisca, GO, Alamanda, VK, Archer, KR, Song, Y, Schwartz, HS & Holt, GE 2013, 'Tumor size increase following preoperative radiation of soft tissue sarcomas does not affect prognosis', Journal of Surgical Oncology, vol. 107, no. 7, pp. 723-727. https://doi.org/10.1002/jso.23322
Delisca, Gadini O. ; Alamanda, Vignesh K. ; Archer, Kristin R. ; Song, Yanna ; Schwartz, Herbert S. ; Holt, Ginger E. / Tumor size increase following preoperative radiation of soft tissue sarcomas does not affect prognosis. In: Journal of Surgical Oncology. 2013 ; Vol. 107, No. 7. pp. 723-727.
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abstract = "Background and Objectives Administration of preoperative radiotherapy for extremity soft tissue sarcoma improves local control, while allowing for a more conservative surgical resection. During radiation treatment tumor size typically decreases or remains constant. In a subset of patients, however, a size increase in the tumor occurs. Our goal was to investigate the prognosis of patients who had a size increase of at least 20{\%} over the course of preoperative radiotherapy versus those who did not. Methods This retrospective study evaluated 70 patients treated for localized primary STS of the extremities between January 2000 and December 2008. Kaplan-Meier curves for disease-specific and metastasis-free survival were calculated for both groups. Results Sixty-one patients had stable or decrease local tumor size following preoperative radiotherapy and nine patients had an increase of at least 20{\%} in tumor size. There were no statistically significant differences found in disease-specific survival and metastasis-free survival (Gray's test, P = 0.93 and P = 0.68, respectively) among the two groups. Conclusion Our results indicate that a 20{\%} increase in tumor size following preoperative radiotherapy did not result in a worse outcome for patients when compared to those who had stable or decrease local tumor size following preoperative radiotherapy.",
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