Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer

Nephtali R. Gomez, Guennadi Kouniavsky, Hua Ling Tsai, Helina Somervell, Sara I. Pai, Ralph P Tufano, Christopher B Umbricht, Jeanne Kowalski, Alan P B Dackiw, Martha A. Zeiger

Research output: Contribution to journalArticle

Abstract

Background and Objectives: Lymph node metastases in papillary thyroid cancer (PTC) are common and their presence can significantly alter the treatment for patients with PTC. We therefore sought to identify pre-operative predictors of lymph node metastases in patients with PTC. Methods: A thyroid tumor database was queried to identify patients with a pre-operative diagnosis of PTC and underwent thyroidectomy between January 2006 and August 2009. One hundred and three patients who had a pre-operative ultrasound and had lymph nodes surgically resected were identified. Clinical factors and tumor ultrasound characteristics were recorded. The pre-operative ultrasound Results:, type of operation, and final pathology Results: were also recorded. Results: Of the 103 patients, 74 (72%) were women and 29 (28%) were men with an age range of 15-78 years (median age of 43). Of the ultrasound characteristics evaluated only calcifications (P=0.007) and size (P=0.003) werestatistically associated with positive cervicallymph nodes. Noneofthe other demographic or clinical factors were significantly associated with lymph node metastases. Conclusions Thyroid nodule size and presence of calcifications on ultrasound were found to have a statistically significant association with lymph node metastases in patients with PTC. This information could be used to guide the surgical management of these patients.

Original languageEnglish (US)
Pages (from-to)613-616
Number of pages4
JournalJournal of Surgical Oncology
Volume104
Issue number6
DOIs
StatePublished - Nov 1 2011

Fingerprint

Ultrasonography
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Thyroid Nodule
Thyroidectomy
Papillary Thyroid cancer
Thyroid Gland
Demography
Databases
Pathology

Keywords

  • lymph node metastases
  • papillary thyroid cancer
  • predictors
  • ultrasound

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer. / Gomez, Nephtali R.; Kouniavsky, Guennadi; Tsai, Hua Ling; Somervell, Helina; Pai, Sara I.; Tufano, Ralph P; Umbricht, Christopher B; Kowalski, Jeanne; Dackiw, Alan P B; Zeiger, Martha A.

In: Journal of Surgical Oncology, Vol. 104, No. 6, 01.11.2011, p. 613-616.

Research output: Contribution to journalArticle

Gomez, Nephtali R. ; Kouniavsky, Guennadi ; Tsai, Hua Ling ; Somervell, Helina ; Pai, Sara I. ; Tufano, Ralph P ; Umbricht, Christopher B ; Kowalski, Jeanne ; Dackiw, Alan P B ; Zeiger, Martha A. / Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer. In: Journal of Surgical Oncology. 2011 ; Vol. 104, No. 6. pp. 613-616.
@article{7d590f1979334adbbe72047091c6862b,
title = "Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer",
abstract = "Background and Objectives: Lymph node metastases in papillary thyroid cancer (PTC) are common and their presence can significantly alter the treatment for patients with PTC. We therefore sought to identify pre-operative predictors of lymph node metastases in patients with PTC. Methods: A thyroid tumor database was queried to identify patients with a pre-operative diagnosis of PTC and underwent thyroidectomy between January 2006 and August 2009. One hundred and three patients who had a pre-operative ultrasound and had lymph nodes surgically resected were identified. Clinical factors and tumor ultrasound characteristics were recorded. The pre-operative ultrasound Results:, type of operation, and final pathology Results: were also recorded. Results: Of the 103 patients, 74 (72{\%}) were women and 29 (28{\%}) were men with an age range of 15-78 years (median age of 43). Of the ultrasound characteristics evaluated only calcifications (P=0.007) and size (P=0.003) werestatistically associated with positive cervicallymph nodes. Noneofthe other demographic or clinical factors were significantly associated with lymph node metastases. Conclusions Thyroid nodule size and presence of calcifications on ultrasound were found to have a statistically significant association with lymph node metastases in patients with PTC. This information could be used to guide the surgical management of these patients.",
keywords = "lymph node metastases, papillary thyroid cancer, predictors, ultrasound",
author = "Gomez, {Nephtali R.} and Guennadi Kouniavsky and Tsai, {Hua Ling} and Helina Somervell and Pai, {Sara I.} and Tufano, {Ralph P} and Umbricht, {Christopher B} and Jeanne Kowalski and Dackiw, {Alan P B} and Zeiger, {Martha A.}",
year = "2011",
month = "11",
day = "1",
doi = "10.1002/jso.21891",
language = "English (US)",
volume = "104",
pages = "613--616",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Tumor size and presence of calcifications on ultrasonography are pre-operative predictors of lymph node metastases in patients with papillary thyroid cancer

AU - Gomez, Nephtali R.

AU - Kouniavsky, Guennadi

AU - Tsai, Hua Ling

AU - Somervell, Helina

AU - Pai, Sara I.

AU - Tufano, Ralph P

AU - Umbricht, Christopher B

AU - Kowalski, Jeanne

AU - Dackiw, Alan P B

AU - Zeiger, Martha A.

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Background and Objectives: Lymph node metastases in papillary thyroid cancer (PTC) are common and their presence can significantly alter the treatment for patients with PTC. We therefore sought to identify pre-operative predictors of lymph node metastases in patients with PTC. Methods: A thyroid tumor database was queried to identify patients with a pre-operative diagnosis of PTC and underwent thyroidectomy between January 2006 and August 2009. One hundred and three patients who had a pre-operative ultrasound and had lymph nodes surgically resected were identified. Clinical factors and tumor ultrasound characteristics were recorded. The pre-operative ultrasound Results:, type of operation, and final pathology Results: were also recorded. Results: Of the 103 patients, 74 (72%) were women and 29 (28%) were men with an age range of 15-78 years (median age of 43). Of the ultrasound characteristics evaluated only calcifications (P=0.007) and size (P=0.003) werestatistically associated with positive cervicallymph nodes. Noneofthe other demographic or clinical factors were significantly associated with lymph node metastases. Conclusions Thyroid nodule size and presence of calcifications on ultrasound were found to have a statistically significant association with lymph node metastases in patients with PTC. This information could be used to guide the surgical management of these patients.

AB - Background and Objectives: Lymph node metastases in papillary thyroid cancer (PTC) are common and their presence can significantly alter the treatment for patients with PTC. We therefore sought to identify pre-operative predictors of lymph node metastases in patients with PTC. Methods: A thyroid tumor database was queried to identify patients with a pre-operative diagnosis of PTC and underwent thyroidectomy between January 2006 and August 2009. One hundred and three patients who had a pre-operative ultrasound and had lymph nodes surgically resected were identified. Clinical factors and tumor ultrasound characteristics were recorded. The pre-operative ultrasound Results:, type of operation, and final pathology Results: were also recorded. Results: Of the 103 patients, 74 (72%) were women and 29 (28%) were men with an age range of 15-78 years (median age of 43). Of the ultrasound characteristics evaluated only calcifications (P=0.007) and size (P=0.003) werestatistically associated with positive cervicallymph nodes. Noneofthe other demographic or clinical factors were significantly associated with lymph node metastases. Conclusions Thyroid nodule size and presence of calcifications on ultrasound were found to have a statistically significant association with lymph node metastases in patients with PTC. This information could be used to guide the surgical management of these patients.

KW - lymph node metastases

KW - papillary thyroid cancer

KW - predictors

KW - ultrasound

UR - http://www.scopus.com/inward/record.url?scp=80053602348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053602348&partnerID=8YFLogxK

U2 - 10.1002/jso.21891

DO - 10.1002/jso.21891

M3 - Article

VL - 104

SP - 613

EP - 616

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 6

ER -