Tumor Site and Breast Cancer Prognosis

Charalampos Siotos, Michael McColl, Kevin Psoter, Richard C. Gilmore, Mohamad E. Sebai, Kristen Broderick, Lisa Jacobs, Stephanie Irwin, Gedge David Rosson, Mehran Habibi

Research output: Contribution to journalArticle

Abstract

The present study is a retrospective review of a prospectively collected institutional cancer registry. We evaluated more than 5000 patients to explore the role of primary tumor location in breast cancer prognosis. Our results indicate that tumors of different primary tumor sites in the breast behave differently and survival differences should be expected. Introduction: Various factors affect breast cancer prognosis; however, little information is available regarding the role of primary tumor site. The purpose of this study was to compare the survival and clinicopathologic characteristics of patients with breast cancer by primary tumor location. Materials and Methods: We analyzed a prospectively collected single-institution breast cancer registry. Univariate and multivariable analyses were used to evaluate the association of tumor site with positive lymph node status, presence of metastasis, time to recurrence or death, and events of recurrence or death. Patients with tumors originating from the upper-outer quadrant were the reference group. Results: From 2003 to 2015, 5295 patients with breast cancer were identified. Tumors originated from the upper-outer quadrant (36.2%), upper-inner quadrant (13.1%), lower-outer quadrant (9.8%), lower-inner quadrant (7.6%), nipple (1.2%), axillary tail (0.3%), or overlapping (24.7%). Tumors originated from overlapping lesions (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.36-1.83) had higher odds of positive axillary lymph nodes, whereas tumors from the upper-inner (OR, 0.68; 95% CI, 0.56-0.84) and lower-inner quadrant (OR, 0.72; 95% CI, 0.56-0.93) had lower odds. Tumors from the lower-outer quadrant were associated with lower risk of death (hazard ratio, 0.64; 95% CI, 0.46-0.88), whereas tumors from overlapping lesions had higher risk (hazard ratio, 1.28; 95% CI, 1.05-1.55). Conclusion: The site of primary tumor may be an important characteristic affecting the prognosis of patients with breast cancer.

Original languageEnglish (US)
JournalClinical Breast Cancer
DOIs
StateAccepted/In press - Jan 1 2018

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Breast Neoplasms
Neoplasms
Confidence Intervals
Odds Ratio
Registries
Lymph Nodes
Recurrence
Survival
Nipples
Breast
Neoplasm Metastasis

Keywords

  • Humans
  • Primary tumor site
  • Recurrences
  • Registries
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Tumor Site and Breast Cancer Prognosis. / Siotos, Charalampos; McColl, Michael; Psoter, Kevin; Gilmore, Richard C.; Sebai, Mohamad E.; Broderick, Kristen; Jacobs, Lisa; Irwin, Stephanie; Rosson, Gedge David; Habibi, Mehran.

In: Clinical Breast Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Siotos, Charalampos ; McColl, Michael ; Psoter, Kevin ; Gilmore, Richard C. ; Sebai, Mohamad E. ; Broderick, Kristen ; Jacobs, Lisa ; Irwin, Stephanie ; Rosson, Gedge David ; Habibi, Mehran. / Tumor Site and Breast Cancer Prognosis. In: Clinical Breast Cancer. 2018.
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abstract = "The present study is a retrospective review of a prospectively collected institutional cancer registry. We evaluated more than 5000 patients to explore the role of primary tumor location in breast cancer prognosis. Our results indicate that tumors of different primary tumor sites in the breast behave differently and survival differences should be expected. Introduction: Various factors affect breast cancer prognosis; however, little information is available regarding the role of primary tumor site. The purpose of this study was to compare the survival and clinicopathologic characteristics of patients with breast cancer by primary tumor location. Materials and Methods: We analyzed a prospectively collected single-institution breast cancer registry. Univariate and multivariable analyses were used to evaluate the association of tumor site with positive lymph node status, presence of metastasis, time to recurrence or death, and events of recurrence or death. Patients with tumors originating from the upper-outer quadrant were the reference group. Results: From 2003 to 2015, 5295 patients with breast cancer were identified. Tumors originated from the upper-outer quadrant (36.2{\%}), upper-inner quadrant (13.1{\%}), lower-outer quadrant (9.8{\%}), lower-inner quadrant (7.6{\%}), nipple (1.2{\%}), axillary tail (0.3{\%}), or overlapping (24.7{\%}). Tumors originated from overlapping lesions (odds ratio [OR], 1.58; 95{\%} confidence interval [CI], 1.36-1.83) had higher odds of positive axillary lymph nodes, whereas tumors from the upper-inner (OR, 0.68; 95{\%} CI, 0.56-0.84) and lower-inner quadrant (OR, 0.72; 95{\%} CI, 0.56-0.93) had lower odds. Tumors from the lower-outer quadrant were associated with lower risk of death (hazard ratio, 0.64; 95{\%} CI, 0.46-0.88), whereas tumors from overlapping lesions had higher risk (hazard ratio, 1.28; 95{\%} CI, 1.05-1.55). Conclusion: The site of primary tumor may be an important characteristic affecting the prognosis of patients with breast cancer.",
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AU - Siotos, Charalampos

AU - McColl, Michael

AU - Psoter, Kevin

AU - Gilmore, Richard C.

AU - Sebai, Mohamad E.

AU - Broderick, Kristen

AU - Jacobs, Lisa

AU - Irwin, Stephanie

AU - Rosson, Gedge David

AU - Habibi, Mehran

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N2 - The present study is a retrospective review of a prospectively collected institutional cancer registry. We evaluated more than 5000 patients to explore the role of primary tumor location in breast cancer prognosis. Our results indicate that tumors of different primary tumor sites in the breast behave differently and survival differences should be expected. Introduction: Various factors affect breast cancer prognosis; however, little information is available regarding the role of primary tumor site. The purpose of this study was to compare the survival and clinicopathologic characteristics of patients with breast cancer by primary tumor location. Materials and Methods: We analyzed a prospectively collected single-institution breast cancer registry. Univariate and multivariable analyses were used to evaluate the association of tumor site with positive lymph node status, presence of metastasis, time to recurrence or death, and events of recurrence or death. Patients with tumors originating from the upper-outer quadrant were the reference group. Results: From 2003 to 2015, 5295 patients with breast cancer were identified. Tumors originated from the upper-outer quadrant (36.2%), upper-inner quadrant (13.1%), lower-outer quadrant (9.8%), lower-inner quadrant (7.6%), nipple (1.2%), axillary tail (0.3%), or overlapping (24.7%). Tumors originated from overlapping lesions (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.36-1.83) had higher odds of positive axillary lymph nodes, whereas tumors from the upper-inner (OR, 0.68; 95% CI, 0.56-0.84) and lower-inner quadrant (OR, 0.72; 95% CI, 0.56-0.93) had lower odds. Tumors from the lower-outer quadrant were associated with lower risk of death (hazard ratio, 0.64; 95% CI, 0.46-0.88), whereas tumors from overlapping lesions had higher risk (hazard ratio, 1.28; 95% CI, 1.05-1.55). Conclusion: The site of primary tumor may be an important characteristic affecting the prognosis of patients with breast cancer.

AB - The present study is a retrospective review of a prospectively collected institutional cancer registry. We evaluated more than 5000 patients to explore the role of primary tumor location in breast cancer prognosis. Our results indicate that tumors of different primary tumor sites in the breast behave differently and survival differences should be expected. Introduction: Various factors affect breast cancer prognosis; however, little information is available regarding the role of primary tumor site. The purpose of this study was to compare the survival and clinicopathologic characteristics of patients with breast cancer by primary tumor location. Materials and Methods: We analyzed a prospectively collected single-institution breast cancer registry. Univariate and multivariable analyses were used to evaluate the association of tumor site with positive lymph node status, presence of metastasis, time to recurrence or death, and events of recurrence or death. Patients with tumors originating from the upper-outer quadrant were the reference group. Results: From 2003 to 2015, 5295 patients with breast cancer were identified. Tumors originated from the upper-outer quadrant (36.2%), upper-inner quadrant (13.1%), lower-outer quadrant (9.8%), lower-inner quadrant (7.6%), nipple (1.2%), axillary tail (0.3%), or overlapping (24.7%). Tumors originated from overlapping lesions (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.36-1.83) had higher odds of positive axillary lymph nodes, whereas tumors from the upper-inner (OR, 0.68; 95% CI, 0.56-0.84) and lower-inner quadrant (OR, 0.72; 95% CI, 0.56-0.93) had lower odds. Tumors from the lower-outer quadrant were associated with lower risk of death (hazard ratio, 0.64; 95% CI, 0.46-0.88), whereas tumors from overlapping lesions had higher risk (hazard ratio, 1.28; 95% CI, 1.05-1.55). Conclusion: The site of primary tumor may be an important characteristic affecting the prognosis of patients with breast cancer.

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KW - Recurrences

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