Tumor necrosis factor, interleukin-1 and beta 2-microglobulin levels in chronic hemodialysis patients

R. J. Caruana, S. A. Lobel, M. S. Leffell, H. Campbell, P. L. Cheek

Research output: Contribution to journalArticle

Abstract

We measured tumor necrosis factor (TNFα), interleukin-1 (IL1-B), and beta-2 microglobulin (B2M) levels in 10 chronic hemodialysis patients before and during dialysis with six different dialysate/dialyzer combinations. The mean pre-dialysis serum level of B2M was 23.4 ± 11.1 mg/L (nl < 3 mg/L). There was no significant effect of hemodialysis with any dialysate/dialyzer combination on intradialytic serum B2M levels. Five patients had detectable pre-dialysis serum levels of TNFα ( >40 pg/ml) at least once and 2 had detectable levels prior to all dialyses. Six patients had detectable pre-dialysis serum levels of IL1-B ( >20 pg/ml) at least once, and 2 had detectable levels prior to all dialyses. Serum TNFα, IL1-B and B2M levels were not significantly correlated with one another. Our data do not support the hypothesis that blood-membrane interactions significantly affect circulating levels of TNFα, IL1-B or B2M. Chronic high level elevations of plasma IL1-B and TNFα are not uniformly observed in hemodialysis patients, arguing against a role for these substances as systemic uremic toxins.

Original languageEnglish (US)
Pages (from-to)794-798
Number of pages5
JournalInternational Journal of Artificial Organs
Volume13
Issue number12
StatePublished - Dec 1 1990

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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  • Cite this

    Caruana, R. J., Lobel, S. A., Leffell, M. S., Campbell, H., & Cheek, P. L. (1990). Tumor necrosis factor, interleukin-1 and beta 2-microglobulin levels in chronic hemodialysis patients. International Journal of Artificial Organs, 13(12), 794-798.