Tumor-induced osteomalacia

Research output: Contribution to journalArticle

Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and extensive laboratory evaluation, tumor-induced osteomalacia was identified as the basis of her clinical presentation. In this article, the distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.

Original languageEnglish (US)
Pages (from-to)1260-1267
Number of pages8
JournalJournal of the American Medical Association
Volume294
Issue number10
DOIs
StatePublished - Sep 14 2005

Fingerprint

Hypophosphatemia
Osteomalacia
Myalgia
Vitamin D
Fatigue
Phosphates
Kidney
Bone and Bones
Oncogenic osteomalacia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tumor-induced osteomalacia. / Jan De Beur, Suzanne M.

In: Journal of the American Medical Association, Vol. 294, No. 10, 14.09.2005, p. 1260-1267.

Research output: Contribution to journalArticle

@article{8a0ba5d67d294cba8e9803836be759bd,
title = "Tumor-induced osteomalacia",
abstract = "Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and extensive laboratory evaluation, tumor-induced osteomalacia was identified as the basis of her clinical presentation. In this article, the distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.",
author = "{Jan De Beur}, {Suzanne M}",
year = "2005",
month = "9",
day = "14",
doi = "10.1001/jama.294.10.1260",
language = "English (US)",
volume = "294",
pages = "1260--1267",
journal = "JAMA - Journal of the American Medical Association",
issn = "0098-7484",
publisher = "American Medical Association",
number = "10",

}

TY - JOUR

T1 - Tumor-induced osteomalacia

AU - Jan De Beur, Suzanne M

PY - 2005/9/14

Y1 - 2005/9/14

N2 - Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and extensive laboratory evaluation, tumor-induced osteomalacia was identified as the basis of her clinical presentation. In this article, the distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.

AB - Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and extensive laboratory evaluation, tumor-induced osteomalacia was identified as the basis of her clinical presentation. In this article, the distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.

UR - http://www.scopus.com/inward/record.url?scp=24644460574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24644460574&partnerID=8YFLogxK

U2 - 10.1001/jama.294.10.1260

DO - 10.1001/jama.294.10.1260

M3 - Article

C2 - 16160135

AN - SCOPUS:24644460574

VL - 294

SP - 1260

EP - 1267

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0098-7484

IS - 10

ER -