Tumor-induced osteomalacia

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Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and extensive laboratory evaluation, tumor-induced osteomalacia was identified as the basis of her clinical presentation. In this article, the distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.

Original languageEnglish (US)
Pages (from-to)1260-1267
Number of pages8
JournalJournal of the American Medical Association
Volume294
Issue number10
DOIs
StatePublished - Sep 14 2005

ASJC Scopus subject areas

  • Medicine(all)

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