Tumor immunology and cancer immunotherapy: Summary of the 2014 SITC primer

David B. Page, Ariel Bulua Bourla, Anthony Daniyan, Jarushka Naidoo, Eric Smith, Melody Smith, Claire Friedman, Danny N. Khalil, Samuel Funt, Alexander N. Shoushtari, Willem W. Overwijk, Padmanee Sharma, Margaret K. Callahan

Research output: Contribution to journalArticlepeer-review

Abstract

The pioneers of tumor immunology and cancer immunotherapy, including the late William B. Coley and Lloyd J. Old, have championed the potential for immunotherapy for over a century. Finally, advances in our understanding of the fundamentals of tumor immunology are translating into clinical success, with recent US Food and Drug Administration approval of several immunotherapies that improve clinical outcomes across prostate cancer, metastatic melanoma, non-small cell lung cancer and lymphocytic leukemia. In tandem with these clinical successes, new technologies such as high-throughput DNA/RNA sequencing, genetic engineering, and streamlined ex vivo cell culturing have paved the way for the next generation of immunotherapies and provided new tools for investigating potential biomarkers of response to existing therapies. During the November 2014 Annual Meeting of the Society of the Immunotherapy of Cancer, leaders in tumor immunology and cancer immunotherapy convened at the second annual SITC Primer to review both current knowledge and future directions in the field. Here, we will review the key discussions across a variety of topics, including innate immunity, adaptive immunity, dendritic cells, adoptive T cell therapy, anti-tumor antibodies, cancer vaccines, immune checkpoint blockade, challenges to immunotherapy, monitoring immune responses, and immunotherapy clinical trial design.

Original languageEnglish (US)
Article number25
JournalJournal for immunotherapy of cancer
Volume3
Issue number1
DOIs
StatePublished - Jun 16 2015
Externally publishedYes

Keywords

  • Adoptive therapy
  • Bladder cancer
  • CTLA4
  • Ipilimumab
  • Kidney cancer
  • Lung cancer
  • Melanoma
  • Nivolumab
  • PD-1
  • PD-L1
  • Pembrolizumab
  • Primer
  • Prostate cancer
  • SITC
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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