Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee; Myung Sook Huh; Seung Young Lee; Solki Min; Seulki Lee; Heebeom Koo; Jun Uk Chu; Kyung Eun Lee; Hyesung Jeon; Yongseok Choi; Kuiwon Choi; Youngro Byun; Seo Young Jeong; Kinam Park; Kwangmeyung Kim; Ick Chan Kwon

doi:10.1002/anie.201201390

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee, Myung Sook Huh, Seung Young Lee, Solki Min, Seulki Lee, Heebeom Koo, Jun Uk Chu, Kyung Eun Lee, Hyesung Jeon, Yongseok Choi, Kuiwon Choi, Youngro Byun, Seo Young Jeong, Kinam Park, Kwangmeyung Kim, Ick Chan Kwon

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

Original language	English (US)
Pages (from-to)	7203-7207
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	29
DOIs	https://doi.org/10.1002/anie.201201390
State	Published - Jul 16 2012
Externally published	Yes

Keywords

Antitumor agents
Glycol chitosan
Nanoparticles
Poly-siRNA
SiRNA delivery

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201201390

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Lee, S. J., Huh, M. S., Lee, S. Y., Min, S., Lee, S., Koo, H., Chu, J. U., Lee, K. E., Jeon, H., Choi, Y., Choi, K., Byun, Y., Jeong, S. Y., Park, K., Kim, K., & Kwon, I. C. (2012). Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment. Angewandte Chemie - International Edition, 51(29), 7203-7207. https://doi.org/10.1002/anie.201201390

Lee, SJ, Huh, MS, Lee, SY, Min, S, Lee, S, Koo, H, Chu, JU, Lee, KE, Jeon, H, Choi, Y, Choi, K, Byun, Y, Jeong, SY, Park, K, Kim, K & Kwon, IC 2012, 'Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment', Angewandte Chemie - International Edition, vol. 51, no. 29, pp. 7203-7207. https://doi.org/10.1002/anie.201201390

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abstract = "The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.",

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doi = "10.1002/anie.201201390",

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AU - Lee, Seulki

AU - Koo, Heebeom

AU - Chu, Jun Uk

AU - Lee, Kyung Eun

AU - Jeon, Hyesung

AU - Choi, Yongseok

AU - Choi, Kuiwon

AU - Byun, Youngro

AU - Jeong, Seo Young

AU - Park, Kinam

AU - Kim, Kwangmeyung

AU - Kwon, Ick Chan

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AB - The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

KW - Antitumor agents

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KW - Nanoparticles

KW - Poly-siRNA

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Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

Abstract

Keywords

ASJC Scopus subject areas

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