Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee, Myung Sook Huh, Seung Young Lee, Solki Min, Seulki Lee, Heebeom Koo, Jun Uk Chu, Kyung Eun Lee, Hyesung Jeon, Yongseok Choi, Kuiwon Choi, Youngro Byun, Seo Young Jeong, Kinam Park, Kwangmeyung Kim, Ick Chan Kwon

Research output: Contribution to journalArticle

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

Original languageEnglish (US)
Pages (from-to)7203-7207
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number29
DOIs
Publication statusPublished - Jul 16 2012
Externally publishedYes

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Keywords

  • Antitumor agents
  • Glycol chitosan
  • Nanoparticles
  • Poly-siRNA
  • SiRNA delivery

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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